Literature DB >> 8019423

MIF proteins are not glutathione transferase homologs.

W R Pearson1.   

Abstract

Although macrophage migration inhibitory factor (MIF) proteins conjugate glutathione, sequence analysis does not support their homology to other glutathione transferases. Glutathione transferases are not detected with MIF proteins in searches of protein sequence databases, and MIF proteins do not share significant sequence similarity with glutathione transferases. Homology cannot be demonstrated by multiple sequence alignment or evolutionary tree construction; such methods assume that the proteins being analyzed are homologous.

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Year:  1994        PMID： 8019423      PMCID： PMC2142705          DOI： 10.1002/pro.5560030318

Source DB:  PubMed          Journal:  Protein Sci        ISSN： 0961-8368            Impact factor:   6.725


  3 in total

1.  Pattern-induced multi-sequence alignment (PIMA) algorithm employing secondary structure-dependent gap penalties for use in comparative protein modelling.

Authors:  R F Smith; T F Smith
Journal:  Protein Eng       Date:  1992-01

2.  MIF protein are theta-class glutathione S-transferase homologs.

Authors:  F A Blocki; L B Ellis; L P Wackett
Journal:  Protein Sci       Date:  1993-12       Impact factor: 6.725

3.  An evolutionary perspective on glutathione transferases inferred from class-theta glutathione transferase cDNA sequences.

Authors:  S E Pemble; J B Taylor
Journal:  Biochem J       Date:  1992-11-01       Impact factor: 3.857
  3 in total
  4 in total

1.  NMR characterization of structure, backbone dynamics, and glutathione binding of the human macrophage migration inhibitory factor (MIF).

Authors:  P Mühlhahn; J Bernhagen; M Czisch; J Georgescu; C Renner; A Ross; R Bucala; T A Holak
Journal:  Protein Sci       Date:  1996-10       Impact factor: 6.725

2.  Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex.

Authors:  M Coggan; L Whitbread; A Whittington; P Board
Journal:  Biochem J       Date:  1998-09-15       Impact factor: 3.857

3.  Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor.

Authors:  H W Sun; J Bernhagen; R Bucala; E Lolis
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-28       Impact factor: 11.205

4.  Brain miffed by macrophage migration inhibitory factor.

Authors:  Nic E Savaskan; Günter Fingerle-Rowson; Michael Buchfelder; Ilker Y Eyüpoglu
Journal:  Int J Cell Biol       Date:  2012-09-03
  4 in total

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