OBJECTIVE: To test the hypothesis that intrapartum maternal oxygen administration increases fetal cerebral oxygenation during normal labour. DESIGN: A prospective study comparing changes in fetal cerebral concentrations of oxyhaemoglobin, deoxyhaemoglobin and cerebral blood volume measured by near infrared spectroscopy, before, during and after maternal oxygen administration using a 60% Ventimask. SETTING: Teaching hospital obstetric unit. SUBJECTS: Ten term fetuses during uncomplicated labour. RESULTS: Maternal oxygen administration for 15 min resulted in a significant increase in the mean concentration of fetal cerebral oxyhaemoglobin (0.78 mumol (SD 0.42) 100 g-1 brain tissue, P < 0.001) and a significant decrease in the mean concentration of deoxyhaemoglobin (0.80 mumol (SD 0.51) 100 g-1, P < 0.001). These changes were associated with a significant increase in the calculated mean cerebral oxygen saturation from 43.9% (SD 6.3) to 57.3% (SD 5.6) (P < 0.001). The maximum rise in cerebral oxyhaemoglobin concentration occurred at a mean of 10.7 min (SD 3.9) following commencement of oxygen administration. On returning to air breathing these changes reversed. There were no changes in cerebral blood volume. CONCLUSION: Maternal oxygen administration during normal labour leads to a significant rise in fetal cerebral oxygenation.
OBJECTIVE: To test the hypothesis that intrapartum maternal oxygen administration increases fetal cerebral oxygenation during normal labour. DESIGN: A prospective study comparing changes in fetal cerebral concentrations of oxyhaemoglobin, deoxyhaemoglobin and cerebral blood volume measured by near infrared spectroscopy, before, during and after maternal oxygen administration using a 60% Ventimask. SETTING: Teaching hospital obstetric unit. SUBJECTS: Ten term fetuses during uncomplicated labour. RESULTS: Maternal oxygen administration for 15 min resulted in a significant increase in the mean concentration of fetal cerebral oxyhaemoglobin (0.78 mumol (SD 0.42) 100 g-1 brain tissue, P < 0.001) and a significant decrease in the mean concentration of deoxyhaemoglobin (0.80 mumol (SD 0.51) 100 g-1, P < 0.001). These changes were associated with a significant increase in the calculated mean cerebral oxygen saturation from 43.9% (SD 6.3) to 57.3% (SD 5.6) (P < 0.001). The maximum rise in cerebral oxyhaemoglobin concentration occurred at a mean of 10.7 min (SD 3.9) following commencement of oxygen administration. On returning to air breathing these changes reversed. There were no changes in cerebral blood volume. CONCLUSION: Maternal oxygen administration during normal labour leads to a significant rise in fetal cerebral oxygenation.
Authors: Lauren M Bullens; Alexandra D J Hulsenboom; Suzanne Moors; Rohan Joshi; Pieter J van Runnard Heimel; M Beatrijs van der Hout-van der Jagt; Edwin R van den Heuvel; S Guid Oei Journal: Trials Date: 2018-03-23 Impact factor: 2.279
Authors: Guifang Fu; Nicholas J A Wan; Joseph M Baker; James W Montgomery; Julia L Evans; Ronald B Gillam Journal: Front Behav Neurosci Date: 2016-06-07 Impact factor: 3.558