OBJECTIVES: Circumstances of delivery among children with acquired immunodeficiency syndrome (AIDS) were investigated to assess whether they were consistent with predictions that intrapartum factors affect the risk of maternal-infant human immunodeficiency virus (HIV) transmission. METHODS: Pediatric AIDS patients (maternal-infant transmission; n = 632) reported to the New York City Health Department through 1991 were compared with a series of infants born to predominantly uninfected women. For each case patient, five control subjects were selected and matched from birth certificate files. Hypothesized case-control comparisons for mode of delivery and preselected complications were tested. RESULTS: Compared with control subjects, case patients were less likely to have been delivered by cesarean section without complications (odds ratio [OR] = 0.77; 95% confidence interval [CI] = 0.59, 1.01) and more likely to have been delivered with complications, whether delivery was by cesarean section (OR = 1.54; 95% CI = 0.98, 2.43) or vaginal (OR = 1.66; 95% CI = 1.15, 2.39). CONCLUSIONS: Assuming that HIV-infected and uninfected women have comparable circumstances of delivery, conditional on sociomedical characteristics, these results suggest that intrapartum events may be associated with maternal-infant HIV transmission.
OBJECTIVES: Circumstances of delivery among children with acquired immunodeficiency syndrome (AIDS) were investigated to assess whether they were consistent with predictions that intrapartum factors affect the risk of maternal-infanthuman immunodeficiency virus (HIV) transmission. METHODS: Pediatric AIDSpatients (maternal-infant transmission; n = 632) reported to the New York City Health Department through 1991 were compared with a series of infants born to predominantly uninfected women. For each case patient, five control subjects were selected and matched from birth certificate files. Hypothesized case-control comparisons for mode of delivery and preselected complications were tested. RESULTS: Compared with control subjects, case patients were less likely to have been delivered by cesarean section without complications (odds ratio [OR] = 0.77; 95% confidence interval [CI] = 0.59, 1.01) and more likely to have been delivered with complications, whether delivery was by cesarean section (OR = 1.54; 95% CI = 0.98, 2.43) or vaginal (OR = 1.66; 95% CI = 1.15, 2.39). CONCLUSIONS: Assuming that HIV-infected and uninfected women have comparable circumstances of delivery, conditional on sociomedical characteristics, these results suggest that intrapartum events may be associated with maternal-infantHIV transmission.
Authors: P A Selwyn; E E Schoenbaum; K Davenny; V J Robertson; A R Feingold; J F Shulman; M M Mayers; R S Klein; G H Friedland; M F Rogers Journal: JAMA Date: 1989-03-03 Impact factor: 56.272
Authors: C Hutto; W P Parks; S H Lai; M T Mastrucci; C Mitchell; J Munoz; E Trapido; I M Master; G B Scott Journal: J Pediatr Date: 1991-03 Impact factor: 4.406
Authors: H L Minkoff; C Henderson; H Mendez; M H Gail; S Holman; A Willoughby; J J Goedett; A Rubinstein; P Stratton; J H Walsh Journal: Am J Obstet Gynecol Date: 1990-11 Impact factor: 8.661
Authors: C Gabiano; P A Tovo; M de Martino; L Galli; C Giaquinto; A Loy; M C Schoeller; M Giovannini; G Ferranti; L Rancilio Journal: Pediatrics Date: 1992-09 Impact factor: 7.124