Literature DB >> 8015777

Extraocular application of mitomycin C in a rabbit model: cytotoxic effects on the ciliary body and epithelium.

H Mietz1, K Addicks, M Diestelhorst, G K Krieglstein.   

Abstract

Since prolonged postoperative hypotony has been a frequent complication of glaucomatous filtration surgery in which mitomycin C (MMC) was used, it is important to determine the intraocular toxic effects of the drug. We placed MMC, in concentrations of 0.05, 0.2, and 1.0 mg/mL on the intact sclera of rabbits and obtained the eyes after 1, 7, and 28 days. Examination of the ciliary epithelium by transmission electron microscopy revealed an electron-dense material near the endoplasmic reticulum. Large intracellular vacuoles were present, and the mitochondria appeared swollen. These findings suggest a toxic effect of MMC on the ciliary epithelium in rabbits after extraocular application, possibly decreasing aqueous production.

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Year:  1994        PMID： 8015777

Source DB:  PubMed          Journal:  Ophthalmic Surg        ISSN： 0022-023X


  9 in total

1.  Toxic effects of subconjunctival 5-fluorouracil and mitomycin C on ciliary body of rats.

Authors:  J Levy; Z Tessler; G Rosenthal; I Klemperer; H J Zirkin; L Kachko; T Lifshitz
Journal:  Int Ophthalmol       Date:  2001       Impact factor: 2.031

2.  Effect of mitomycin C on the optic nerve in rabbits.

Authors:  H Mietz; T C Prager; C Schweitzer; J Patrinely; J R Valenzuela; R L Font
Journal:  Br J Ophthalmol       Date:  1997-07       Impact factor: 4.638

3.  Risk factors for failures of trabeculectomies performed without antimetabolites.

Authors:  H Mietz; B Raschka; G K Krieglstein
Journal:  Br J Ophthalmol       Date:  1999-07       Impact factor: 4.638

4.  Tocotrienol inhibits proliferation of human Tenon's fibroblasts in vitro: a comparative study with vitamin E forms and mitomycin C.

Authors:  Alexander Meyenberg; David Goldblum; Jean-Marc Zingg; Angelo Azzi; Kalanithi Nesaretnam; Monika Kilchenmann; Beatrice E Frueh
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2005-05-21       Impact factor: 3.117

5.  Postoperative application of mitomycin c improves the complete success rate of primary trabeculectomy: a prospective, randomized trial.

Authors:  Holger Mietz; Günter K Krieglstein
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2006-04-06       Impact factor: 3.117

6.  Short-term clinical results and complications of trabeculectomies performed with mitomycin C using different concentrations.

Authors:  H Mietz; G K Krieglstein
Journal:  Int Ophthalmol       Date:  1995       Impact factor: 2.031

7.  Antifibrotic effects of tocotrienols on human Tenon's fibroblasts.

Authors:  Christoph Tappeiner; Alexander Meyenberg; David Goldblum; Daniel Mojon; Jean-Marc Zingg; Kalanithi Nesaretnam; Monika Kilchenmann; Beatrice E Frueh
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2009-08-14       Impact factor: 3.117

8.  Confocal microscopic examination of trabecular meshwork removed during ab externo trabeculectomy.

Authors:  P Hamard; F Valtot; P Sourdille; F Bourles-Dagonet; C Baudouin
Journal:  Br J Ophthalmol       Date:  2002-09       Impact factor: 4.638

Review 9.  Wound Healing Modulation in Glaucoma Filtration Surgery-Conventional Practices and New Perspectives: The Role of Antifibrotic Agents (Part I).

Authors:  Jennifer C Fan Gaskin; Dan Q Nguyen; Ghee Soon Ang; Jeremy O'Connor; Jonathan G Crowston
Journal:  J Curr Glaucoma Pract       Date:  2014-06-12
  9 in total

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