| Literature DB >> 8015729 |
K B Ahern1, H S Lustig, D A Greenberg.
Abstract
Exposure of rat cerebrocortical cultures to 100 mM ethanol for 3-4 days increased both the neurotoxic potency of N-methyl-D-aspartate (NMDA) and the maximal extent of NMDA-induced intracellular calcium (Ca2+i) elevations. In both control and ethanol-treated cultures, NMDA toxicity correlated closely with [Ca2+]i. Enhancement of NMDA responses may reflect neuronal adaptation to chronic ethanol exposure and could contribute to the pathogenesis of alcohol-related neurologic disorders.Entities:
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Year: 1994 PMID： 8015729 DOI： 10.1016/0304-3940(94)90747-1
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046