Literature DB >> 8014381

[3H]GABA uptake and GABA localization in mucosal endocrine cells of the rat stomach and colon.

A Krantis1, K Tufts, K Nichols, G P Morris.   

Abstract

The aim of this study was to characterize the distribution of GABAergic cells in the rat gut mucosa. Thin and/or thick serial sections of segments of rat antrum and distal colon were treated for autoradiographic localization of sites of [3H]GABA (50 nM) high-affinity uptake, or GABA immunoreactivity. Dense accumulations of silver grains were localized to a discrete population of granulated mucosal cells. These appeared to be D-type endocrine cells. These gut regions also displayed strongly GABA-immunoreactive mucosal cells. These results confirm the presence of GABAergic cells in the rat antral mucosa, and reveal that [3H]GABA is accumulated by mucosal endocrine cells in the rat colon.

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Year:  1994        PMID： 8014381     DOI： 10.1016/0165-1838(94)90183-x

Source DB:  PubMed          Journal:  J Auton Nerv Syst        ISSN： 0165-1838


  9 in total

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