OBJECTIVE: Does positive end-expiratory pressure ventilation (PEEP) deteriorate cardiac contractility? DESIGN: By means of echocardiography nine piglets were studies during ventilation with 0, 15 and 25 cmH2O (PEEP). Recordings were made before and after 500 ml of 6% dextran 70. MEASUREMENT AND RESULTS: Right and left ventricular end-diastolic diameters were plotted against the stroke volume determined by the thermodilution technique. By combining observations made before and after volume expansion during the different ventilation modes, a ventricular function curve was obtained. The slopes of the curves were similar during all three ventilation modes, both on the left and on the right side. CONCLUSION: This study indicates undisturbed myocardial contractility during PEEP ventilation. We infer that the cardiac output deterioration in the intact animal is caused entirely by impairment of venous return.
OBJECTIVE: Does positive end-expiratory pressure ventilation (PEEP) deteriorate cardiac contractility? DESIGN: By means of echocardiography nine piglets were studies during ventilation with 0, 15 and 25 cmH2O (PEEP). Recordings were made before and after 500 ml of 6% dextran 70. MEASUREMENT AND RESULTS: Right and left ventricular end-diastolic diameters were plotted against the stroke volume determined by the thermodilution technique. By combining observations made before and after volume expansion during the different ventilation modes, a ventricular function curve was obtained. The slopes of the curves were similar during all three ventilation modes, both on the left and on the right side. CONCLUSION: This study indicates undisturbed myocardial contractility during PEEP ventilation. We infer that the cardiac output deterioration in the intact animal is caused entirely by impairment of venous return.
Authors: B Chernow; S Soldano; D Cook; P Lyons; M Barton; L C Casey; J R Fletcher; C R Lake Journal: Anaesth Intensive Care Date: 1986-11 Impact factor: 1.669
Authors: Tessa Martherus; Kelly J Crossley; Karyn A Rodgers; Janneke Dekker; Anja Demel; Alison M Moxham; Valerie A Zahra; Graeme R Polglase; Calum T Roberts; Arjan B Te Pas; Stuart B Hooper Journal: Front Pediatr Date: 2021-01-22 Impact factor: 3.418
Authors: José Gorrasi; Arturo Pazos; Lucia Florio; Carlos Américo; Natalia Lluberas; Gabriel Parma; Ricardo Lluberas Journal: Rev Bras Ter Intensiva Date: 2019 Oct-Dec