Literature DB >> 8013958

Iron overload in beta 2-microglobulin-deficient mice.

M de Sousa1, R Reimão, R Lacerda, P Hugo, S H Kaufmann, G Porto.   

Abstract

The present paper describes the results of a comparative histological and quantitative analysis of iron distribution in tissues of beta 2m-/- and beta 2m+/- mice of different ages. Progressive hepatic iron overload, indistinguishable from that observed in human hemochromatosis, was found only in mice homozygous for the mutated beta 2m gene. Total iron measurements done by flame atomic absorption showed statistically significant differences between liver samples from 5 beta 2m+/- heterozygotes (468 +/- 174 micrograms/g of dry weight) and 9 mice homozygous for the mutated beta 2m gene with average total hepatic iron levels of 1583 +/- 423 micrograms/g of dry weight.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 8013958     DOI： 10.1016/0165-2478(94)90094-9

Source DB:  PubMed          Journal:  Immunol Lett        ISSN： 0165-2478            Impact factor:   3.685


  42 in total

1.  The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin.

Authors:  Jian Wang; Guohua Chen; Kostas Pantopoulos
Journal:  Biochem J       Date:  2003-03-15       Impact factor: 3.857

2.  Comparative study between Hfe-/- and beta2m-/- mice: progression with age of iron status and liver pathology.

Authors:  Pedro Rodrigues; Célia Lopes; Claudia Mascarenhas; Paolo Arosio; Graça Porto; Maria De Sousa
Journal:  Int J Exp Pathol       Date:  2006-08       Impact factor: 1.925

Review 3.  Targeted disruption of the HFE gene.

Authors:  E Beutler
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-03       Impact factor: 11.205

4.  Regulation of intestinal non-haem iron absorption.

Authors:  M Lombard; E Chua; P O'Toole
Journal:  Gut       Date:  1997-04       Impact factor: 23.059

5.  Haemochromatosis: a gene at last?

Authors:  K J Robson; J D Shearman; A T Merryweather-Clarke; J J Pointon; W M Rosenberg; A P Walker; J S Dooley; A Bomford; R Raha-Chowdhury; M Worwood
Journal:  J Med Genet       Date:  1997-02       Impact factor: 6.318

6.  Naturally variant autosomal and sex-linked loci determine the severity of iron overload in beta 2-microglobulin-deficient mice.

Authors:  T J Sproule; E C Jazwinska; R S Britton; B R Bacon; R E Fleming; W S Sly; D C Roopenian
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-17       Impact factor: 11.205

7.  Iron overload and heart fibrosis in mice deficient for both beta2-microglobulin and Rag1.

Authors:  M M Santos; M de Sousa; L H Rademakers; H Clevers; J J Marx; M W Schilham
Journal:  Am J Pathol       Date:  2000-12       Impact factor: 4.307

8.  beta2 knockout mice develop parenchymal iron overload: A putative role for class I genes of the major histocompatibility complex in iron metabolism.

Authors:  B E Rothenberg; J R Voland
Journal:  Proc Natl Acad Sci U S A       Date:  1996-02-20       Impact factor: 11.205

9.  Function of the hemochromatosis protein HFE: Lessons from animal models.

Authors:  Kostas Pantopoulos
Journal:  World J Gastroenterol       Date:  2008-12-07       Impact factor: 5.742

10.  Increased susceptibility to Mycobacterium avium in hemochromatosis protein HFE-deficient mice.

Authors:  Sandra Gomes-Pereira; Pedro Nuno Rodrigues; Rui Appelberg; Maria Salomé Gomes
Journal:  Infect Immun       Date:  2008-08-11       Impact factor: 3.441
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.