Literature DB >> 8013649

Interaction of diiodothyronines with isolated cytochrome c oxidase.

F Goglia1, A Lanni, J Barth, B Kadenbach.   

Abstract

Diiodothyronines (3,3'-T2 and 3,5-T2) stimulate the activity of isolated cytochrome c oxidase (COX) from bovine heart mitochondria. Maximal stimulation of activity (about 50%) is obtained with 3,3'-T2 at pH 6.4 and with 3,5-T2 at pH 7.4. In contrast, 3,5,3'-triiodothyronine (T3) exhibited no or little stimulation of COX activity. Binding of the hormones to COX leads to conformational changes as shown by modified visible spectra of the oxidized enzyme. It is suggested that 'short-term' effects of thyroid hormones on mitochondrial respiration are at least partly due to the allosteric interaction of diiodothyronines with the COX complex.

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Year:  1994        PMID： 8013649     DOI： 10.1016/0014-5793(94)00476-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  15 in total

Review 1.  Control of energy metabolism by iodothyronines.

Authors:  A Lanni; M Moreno; A Lombardi; P de Lange; F Goglia
Journal:  J Endocrinol Invest       Date:  2001-12       Impact factor: 4.256

2.  Effect of 3,5-di-iodo-L-thyronine on the mitochondrial energy-transduction apparatus.

Authors:  A Lombardi; A Lanni; M Moreno; M D Brand; F Goglia
Journal:  Biochem J       Date:  1998-02-15       Impact factor: 3.857

3.  Computational prediction and in vitro analysis of potential physiological ligands of the bile acid binding site in cytochrome c oxidase.

Authors:  Leann Buhrow; Carrie Hiser; Jeffrey R Van Voorst; Shelagh Ferguson-Miller; Leslie A Kuhn
Journal:  Biochemistry       Date:  2013-09-27       Impact factor: 3.162

4.  Calorigenic effect of diiodothyronines in the rat.

Authors:  A Lanni; M Moreno; A Lombardi; F Goglia
Journal:  J Physiol       Date:  1996-08-01       Impact factor: 5.182

5.  Toxicity of the flame-retardant BDE-49 on brain mitochondria and neuronal progenitor striatal cells enhanced by a PTEN-deficient background.

Authors:  Eleonora Napoli; Connie Hung; Sarah Wong; Cecilia Giulivi
Journal:  Toxicol Sci       Date:  2013-01-03       Impact factor: 4.849

6.  3,5-Diiodo-L-thyronine activates brown adipose tissue thermogenesis in hypothyroid rats.

Authors:  Assunta Lombardi; Rosalba Senese; Rita De Matteis; Rosa Anna Busiello; Federica Cioffi; Fernando Goglia; Antonia Lanni
Journal:  PLoS One       Date:  2015-02-06       Impact factor: 3.240

7.  The effects of 3,5-diiodothyronine on energy balance.

Authors:  Fernando Goglia
Journal:  Front Physiol       Date:  2015-01-13       Impact factor: 4.566

Review 8.  Effect of Iodothyronines on Thermogenesis: Focus on Brown Adipose Tissue.

Authors:  Federica Cioffi; Alessandra Gentile; Elena Silvestri; Fernando Goglia; Assunta Lombardi
Journal:  Front Endocrinol (Lausanne)       Date:  2018-05-23       Impact factor: 5.555

9.  Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues.

Authors:  Alvaro Souto Padron; Ruy Andrade Louzada Neto; Thiago Urgal Pantaleão; Maria Carolina de Souza dos Santos; Renata Lopes Araujo; Bruno Moulin de Andrade; Monique da Silva Leandro; João Pedro Saar Werneck de Castro; Andrea Claudia Freitas Ferreira; Denise Pires de Carvalho
Journal:  J Endocrinol       Date:  2014-04-01       Impact factor: 4.286

10.  Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet.

Authors:  Liliana F Iannucci; Federica Cioffi; Rosalba Senese; Fernando Goglia; Antonia Lanni; Paul M Yen; Rohit A Sinha
Journal:  Sci Rep       Date:  2017-05-17       Impact factor: 4.379
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