Literature DB >> 8013532

Testosterone treatment enhances thromboxane A2 mimetic induced coronary artery vasoconstriction in guinea pigs.

K Schrör1, T A Morinelli, A Masuda, K Matsuda, R S Mathur, P V Halushka.   

Abstract

Thromboxane A2 (TXA2) has been implicated as an important mediator of cardiovascular diseases. There have been several clinical reports of acute myocardial infarctions occurring in young male athletes abusing anabolic steroids. The effects of treatment of male Guinea pigs with testosterone on the responses to U46619, a TXA2 receptor agonist, in the isolated perfused heart were determined. The maximum pressor responses of the isolated perfused Guinea pig heart to U46619 were significantly (P < 0.05) greater in the Guinea pigs treated with testosterone compared to the controls. These results indicate that testosterone can enhance coronary artery vascular reactivity to TXA2.

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Year:  1994        PMID： 8013532     DOI： 10.1111/j.1365-2362.1994.tb02428.x

Source DB:  PubMed          Journal:  Eur J Clin Invest        ISSN： 0014-2972            Impact factor:   4.686


  18 in total

1.  Differential effects of 17beta-estradiol and testosterone on the contractile responses of porcine coronary arteries.

Authors:  H Teoh; A Quan; S W Leung; R Y Man
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739

2.  The effect of testosterone on regional blood flow in prepubertal anaesthetized pigs.

Authors:  C Molinari; A Battaglia; E Grossini; D A S G Mary; C Vassanelli; G Vacca
Journal:  J Physiol       Date:  2002-08-15       Impact factor: 5.182

Review 3.  Constrictor prostanoids and uridine adenosine tetraphosphate: vascular mediators and therapeutic targets in hypertension and diabetes.

Authors:  Takayuki Matsumoto; Styliani Goulopoulou; Kumiko Taguchi; Rita C Tostes; Tsuneo Kobayashi
Journal:  Br J Pharmacol       Date:  2015-07-08       Impact factor: 8.739

4.  Hostility, testosterone, and vascular reactivity to stress: effects of sex.

Authors:  S S Girdler; L D Jammer; D Shapiro
Journal:  Int J Behav Med       Date:  1997

5.  Left ventricular dysfunction and subclinical atherosclerosis in children with classic congenital adrenal hyperplasia: a single-center study from upper Egypt.

Authors:  Kotb Abbass Metwalley; Hekma Saad Farghaly; Tahra Sherief
Journal:  Eur J Pediatr       Date:  2015-09-21       Impact factor: 3.183

6.  Medroxyprogesterone acetate and dihydrotestosterone induce coronary hyperreactivity in intact male rhesus monkeys.

Authors:  Rajesh G Mishra; R Kent Hermsmeyer; Koichi Miyagawa; Philip Sarrel; Barry Uchida; Frank Z Stanczyk; Kenneth A Burry; D Roger Illingworth; Frank J Nordt
Journal:  J Clin Endocrinol Metab       Date:  2005-03-15       Impact factor: 5.958

7.  Sex steroids and heart rate variability in patients after myocardial infarction.

Authors:  Jerzy Krzysztof Wranicz; Marcin Rosiak; Iwona Cygankiewicz; Piotr Kula; Krzysztof Kula; Wojciech Zareba
Journal:  Ann Noninvasive Electrocardiol       Date:  2004-04       Impact factor: 1.468

Review 8.  Testosterone and coronary vascular tone: implications in coronary artery disease.

Authors:  F L Wynne; R A Khalil
Journal:  J Endocrinol Invest       Date:  2003-02       Impact factor: 4.256

9.  Metabolomics and incident hypertension among blacks: the atherosclerosis risk in communities study.

Authors:  Yan Zheng; Bing Yu; Danny Alexander; Thomas H Mosley; Gerardo Heiss; Jennifer A Nettleton; Eric Boerwinkle
Journal:  Hypertension       Date:  2013-06-17       Impact factor: 10.190

Review 10.  Non-genomic actions of androgens.

Authors:  C D Foradori; M J Weiser; R J Handa
Journal:  Front Neuroendocrinol       Date:  2007-11-07       Impact factor: 8.606
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