Reference limits in occupational toxicology.

Two categories of reference limits can be discerned in biological monitoring: The first category identifies individuals who have been exposed to a toxic agent at work, and is based on the distribution of the concentration of the agent or its metabolite in the population that has not been exposed to the agent at work. The second category, for which the term biological action level (BAL) is proposed, provides a guideline on the level of exposure that is acceptable. These levels may be either directly health-based or derived from good working practices. Thus BAL is a biological equivalent for the generic term occupational exposure limit. BAL should be independent of legal overtones, and implies that workers' exposure should be reduced.