Literature DB >> 8012891

Delphinium alkaloids as inhibitors of alpha-bungarotoxin binding to rat and insect neural membranes.

C F Kukel1, K R Jennings.   

Abstract

A series of C19-diterpenoid alkaloids purified from Delphinium were evaluated as inhibitors of alpha-bungarotoxin binding to rat and house fly neural membranes. In comparing these diterpenoid analogs, a wide range of inhibition potencies (IC50) were observed, with calculated IC50 values ranging six orders of magnitude. The most potent inhibitory alkaloids in this series possessed the succinimide aromatic ester moiety in the C18 position. Glaudelsine had an IC50 value of 42 pM at the insect nicotinic acetylcholine receptor.

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Year:  1994        PMID： 8012891     DOI： 10.1139/y94-016

Source DB:  PubMed          Journal:  Can J Physiol Pharmacol        ISSN： 0008-4212            Impact factor:   2.273


  9 in total

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Review 7.  Antifungal and Larvicidal Activities of Phlorotannins from Brown Seaweeds.

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Journal:  Mar Drugs       Date:  2021-04-16       Impact factor: 5.118

Review 8.  Structure-Function of Neuronal Nicotinic Acetylcholine Receptor Inhibitors Derived From Natural Toxins.

Authors:  Thao N T Ho; Nikita Abraham; Richard J Lewis
Journal:  Front Neurosci       Date:  2020-11-25       Impact factor: 4.677

9.  Larvicidal Potential of the Halogenated Sesquiterpene (+)-Obtusol, Isolated from the Alga Laurencia dendroidea J. Agardh (Ceramiales: Rhodomelaceae), against the Dengue Vector Mosquito Aedes aegypti (Linnaeus) (Diptera: Culicidae).

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  9 in total

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