| Literature DB >> 8012554 |
K Abe1, A Suzuki, H Katayama, Y Tatsumi, E Yumioka.
Abstract
A sensitive high-performance liquid chromatographic method has been developed for the determination of 18 beta-Glycyrrhetic acid in human plasma. 18 alpha-Glycyrrhetic acid was used as an internal standard. The procedure includes pretreatment by liquid-liquid extraction and chromatographic separation on a reversed-phase column with ultraviolet detection. The detection limit of the drug was 5 ng/ml. The method was applied to the determination of 18 beta-glycyrrhetic acid in plasma after oral administration of a herbal medicine containing 18 beta-glycyrrhitic acid in human volunteers.Entities:
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Year: 1994 PMID： 8012554 DOI： 10.1016/0378-4347(93)e0406-g
Source DB: PubMed Journal: J Chromatogr B Biomed Appl ISSN： 1572-6495