Proteoglycans and glycosaminoglycans in tumor growth and migration: first experience with tumors of bladder and prostate origin.

Proteoglycans (PGs), macromolecules that contain bound glycosaminoglycans (GAGs), are an abundant and ubiquitously distributed group of proteins with a large variety of heterogeneous structures. In recent years a whole range of functions, varying from structural/mechanical support to involvement in the regulation of cell proliferation and cell mobility, cell-cell interactions, and angiogenesis and modulation of the extracellular matrix, have been attributed to these compounds. In this communication an overview is presented dealing with the available knowledge of the (regulatory) properties of PGs and GAGs as participants in tumor growth and metastasis. Acquaintance with the biochemical, biophysical, and biological characteristics of PGs and GAGs may provide a rational basis of the therapeutic use of GAGs in the prevention of tumor growth and invasion. The scarcely available information related to the role of PGs and GAGs in uro-oncology and the potential application of GAGs in the treatment of urological tumors are discussed.