Literature DB >> 8011213

T-cell development and function in gene-knockout mice.

R S Yeung1, J Penninger, T W Mak.   

Abstract

The use of mice with defined genetic defects engineered by homologous recombination in embryonic stem cells has greatly enhanced our understanding of immune functions at the single-gene level. The complex molecular interactions involved in T-cell development and antigen recognition have been especially targeted for detailed analysis via knockout technology.

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Year:  1994        PMID： 8011213     DOI： 10.1016/0952-7915(94)90105-8

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  5 in total

1.  Spontaneous remyelination following extensive demyelination is associated with improved neurological function in a viral model of multiple sclerosis.

Authors:  P D Murray; D B McGavern; S Sathornsumetee; M Rodriguez
Journal:  Brain       Date:  2001-07       Impact factor: 13.501

2.  Is thymocyte development functional in the aged?

Authors:  Danielle Aw; Alberto B Silva; Donald B Palmer
Journal:  Aging (Albany NY)       Date:  2009-02-17       Impact factor: 5.682

3.  Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense.

Authors:  Ilhem Messaoudi; Joël Lemaoult; Jose A Guevara-Patino; Beatrix M Metzner; Janko Nikolich-Zugich
Journal:  J Exp Med       Date:  2004-11-15       Impact factor: 14.307

4.  CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis.

Authors:  P D Murray; K D Pavelko; J Leibowitz; X Lin; M Rodriguez
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103

5.  Nuclear factors that mediate intrathymic signals are developmentally regulated.

Authors:  J Sen; Y Shinkai; F W Alt; R Sen; S J Burakoff
Journal:  J Exp Med       Date:  1994-12-01       Impact factor: 14.307
  5 in total

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