Literature DB >> 8009560

A rational basis for the measurement of free phenytoin concentration in critically ill trauma patients.

S Zielmann1, F Mielck, R Kahl, S Kazmaier, M Sydow, J Kolk, H Burchardi.   

Abstract

Phenytoin binding to serum proteins and factors influencing protein binding were investigated in 38 critically ill trauma patients. In 24% of these patients, the free fraction of phenytoin was < or = 10%, whereas in 76%, the free phenytoin fraction was increased > 10%--up to 24%. Nonantiepileptic comedication, sex, or age had no influence on phenytoin binding in any of the 38 patients. Elevated free phenytoin fraction was found in those with hypoalbuminemia and hepatic and renal impairments. In these patients, the free phenytoin fraction should be measured routinely.

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Year:  1994        PMID： 8009560     DOI： 10.1097/00007691-199404000-00005

Source DB:  PubMed          Journal:  Ther Drug Monit        ISSN： 0163-4356            Impact factor:   3.681


  9 in total

1.  Impaired protein binding of Chinese medicine DanShen in uremic sera and sera with hyperbilirubinemia: rapid assessment of total and free DanShen concentrations using the fluorescence polarization immunoassay for digoxin.

Authors:  Amer Wahed; John Pollard; Alice Wells; Amitava Dasgupta
Journal:  J Clin Lab Anal       Date:  2003       Impact factor: 2.352

Review 2.  Pharmacokinetic and pharmacodynamic considerations when treating patients with sepsis and septic shock.

Authors:  Peter De Paepe; Frans M Belpaire; Walter A Buylaert
Journal:  Clin Pharmacokinet       Date:  2002       Impact factor: 6.447

3.  Validation of a free phenytoin assay on Cobas c501 analyzer using calibrators from Cobas Integra free phenytoin assay by comparing its performance with fluorescence polarization immunoassay for free phenytoin on the TDx analyzer.

Authors:  Amitava Dasgupta; Bonnette Davis; Loretta Chow
Journal:  J Clin Lab Anal       Date:  2013-01       Impact factor: 2.352

Review 4.  Pharmacokinetics of drugs used in critically ill adults.

Authors:  B M Power; A M Forbes; P V van Heerden; K F Ilett
Journal:  Clin Pharmacokinet       Date:  1998-01       Impact factor: 6.447

5.  Pharmacokinetics of ertapenem in critically ill patients receiving continuous venovenous hemodialysis or hemodiafiltration.

Authors:  Rachel F Eyler; A Mary Vilay; Ahmed M Nader; Michael Heung; Melissa Pleva; Kevin M Sowinski; Daryl D DePestel; Fritz Sörgel; Martina Kinzig; Bruce A Mueller
Journal:  Antimicrob Agents Chemother       Date:  2013-12-09       Impact factor: 5.191

6.  Free phenytoin assessment in patients: measured versus calculated blood serum levels.

Authors:  Andrea Tobler; Raphael Hösli; Stefan Mühlebach; Andreas Huber
Journal:  Int J Clin Pharm       Date:  2016-01-08

Review 7.  Pharmacokinetic alterations after severe head injury. Clinical relevance.

Authors:  B A Boucher; S D Hanes
Journal:  Clin Pharmacokinet       Date:  1998-09       Impact factor: 6.447

8.  Correlation between measured and calculated free phenytoin serum concentration in neurointensive care patients with hypoalbuminemia.

Authors:  Seyyede-Sareh Javadi; Reza Mahjub; Abbas Taher; Younes Mohammadi; Maryam Mehrpooya
Journal:  Clin Pharmacol       Date:  2018-12-13

9.  Total Phenytoin concentration is not well correlated with active free drug in critically-ill head trauma patients.

Authors:  Kourosh Sadeghi; Farin Hadi; Arezoo Ahmadi; Hadi Hamishehkar; Mohammad-Taghi Beigmohammadi; Ata Mahmoodpoor; Mohammad Reza Rouini; Shirin Farhudi; Narjes Hendoui; Atabak Najafi; Mojtaba Mojtahedzadeh
Journal:  J Res Pharm Pract       Date:  2013-07
  9 in total

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