Literature DB >> 8008978

Platelet-activating factor (PAF) acetylhydrolase activity, type II phospholipase A2, and cytokine levels in patients with sepsis.

S Endo1, K Inada, H Yamashita, T Takakuwa, H Nakae, T Kasai, M Kikuchi, M Ogawa, K Uchida, M Yoshida.   

Abstract

Platelet activating factor acetylhydrolase (PAF-AH) activity was measured in patients with sepsis, and its relationships with various cytokines and endotoxin were evaluated. PAF-AH activity was significantly higher (p = 0.0136) in 17 patients who died than 13 patients who survived. PAF-AH activity showed significant correlations with the plasma endotoxin, TNF-alpha, and IL-8 levels. These findings suggest that PAF-AH activity reflects the severity of the pathological condition.

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Year:  1994        PMID： 8008978

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN： 0034-5164


  6 in total

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Authors:  Irene F Gazi; Fotini A Apostolou; Evangelos N Liberopoulos; Theodosios D Filippatos; Constantinos C Tellis; Moses S Elisaf; Alexandros D Tselepis
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6.  A Molecular Host Response Assay to Discriminate Between Sepsis and Infection-Negative Systemic Inflammation in Critically Ill Patients: Discovery and Validation in Independent Cohorts.

Authors:  Leo McHugh; Therese A Seldon; Roslyn A Brandon; James T Kirk; Antony Rapisarda; Allison J Sutherland; Jeffrey J Presneill; Deon J Venter; Jeffrey Lipman; Mervyn R Thomas; Peter M C Klein Klouwenberg; Lonneke van Vught; Brendon Scicluna; Marc Bonten; Olaf L Cremer; Marcus J Schultz; Tom van der Poll; Thomas D Yager; Richard B Brandon
Journal:  PLoS Med       Date:  2015-12-08       Impact factor: 11.069
  6 in total

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