Literature DB >> 8006158

Management of spasticity in cerebral palsy with botulinum-A toxin: report of a preliminary, randomized, double-blind trial.

L A Koman1, J F Mooney, B P Smith, A Goodman, T Mulvaney.   

Abstract

In order to evaluate further the efficacy of local intramuscular injections of botulinum-A toxin (BAT-A) in the management of dynamic equinus deformity associated with cerebral palsy, a randomized, double-blind, placebo-controlled study was undertaken. When evaluated using our Physician Rating Scale, 83% (five of six) of patients receiving toxin showed improvement, versus 33% (two of six) receiving placebo. There were no major complications. BAT-A injections appear to be safe and effective in children, and merit further prospective study.

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Year:  1994        PMID： 8006158     DOI： 10.1097/01241398-199405000-00005

Source DB:  PubMed          Journal:  J Pediatr Orthop        ISSN： 0271-6798            Impact factor:   2.324


  34 in total

1.  Development of a video-based evaluation tool in Rett syndrome.

Authors:  S Fyfe; J Downs; O McIlroy; B Burford; J Lister; S Reilly; C L Laurvick; C Philippe; M Msall; W E Kaufmann; C Ellaway; H Leonard
Journal:  J Autism Dev Disord       Date:  2006-12-16

2.  Evaluating the role of botulinum toxin in the management of focal hypertonia in adults.

Authors:  D Richardson; G Sheean; D Werring; M Desai; S Edwards; R Greenwood; A Thompson
Journal:  J Neurol Neurosurg Psychiatry       Date:  2000-10       Impact factor: 10.154

3.  New approaches to managing spasticity in children with cerebral palsy.

Authors:  D Im; C M McDonald
Journal:  West J Med       Date:  1997-04

4.  Botulinum toxin in the cerebral palsies.

Authors:  B Neville
Journal:  BMJ       Date:  1994-12-10

Review 5.  Effectiveness of botulinum toxin A for upper and lower limb spasticity in children with cerebral palsy: a summary of evidence.

Authors:  Marissa Barlaan Lukban; Raymond L Rosales; Dirk Dressler
Journal:  J Neural Transm (Vienna)       Date:  2009-01-14       Impact factor: 3.575

6.  Botulinum toxin injection causes hyper-reflexia and increased muscle stiffness of the triceps surae muscle in the rat.

Authors:  Jessica Pingel; Jacob Wienecke; Jakob Lorentzen; Jens Bo Nielsen
Journal:  J Neurophysiol       Date:  2016-09-14       Impact factor: 2.714

7.  Short-term effects of combined serial casting and botulinum toxin injection for spastic equinus in ambulatory children with cerebral palsy.

Authors:  Eun Sook Park; Dong-Wook Rha; Jun Ki Yoo; Sun Mi Kim; Won Hyuk Chang; Sang Hyuk Song
Journal:  Yonsei Med J       Date:  2010-07       Impact factor: 2.759

Review 8.  Use of botulinum toxin A in adult neurological disorders: efficacy, tolerability and safety.

Authors:  Wilhelm J Schulte-Mattler
Journal:  CNS Drugs       Date:  2008       Impact factor: 5.749

9.  Botulinum Toxin Treatment on Upper Limb Function in School Age Children With Bilateral Spastic Cerebral Palsy: One Year Follow-up.

Authors:  Jee Sun Lee; Kyu Bum Lee; Yu Ryun Lee; You Nam Choi; Chul Woo Park; Sang Duck Park; Dong Hwa Jung; Chul Sang Lee
Journal:  Ann Rehabil Med       Date:  2013-06-30

10.  Position paper on the use of botulinum toxin in cerebral palsy. UK Botulinum Toxin and Cerebral Palsy Working Party.

Authors:  L J Carr; A P Cosgrove; P Gringras; B G Neville
Journal:  Arch Dis Child       Date:  1998-09       Impact factor: 3.791
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