| Literature DB >> 8005288 |
J P Buch1, T F Kolon, N Maulik, D L Kreutzer, D K Das.
Abstract
Reactive oxygen species production has been demonstrated to impair sperm function. We have noted the potential for the cytokines IL-1 alpha, IL-1 beta, and TNF alpha to stimulate reactive oxygen species production by fertile donor sperm at levels that are consistent with the levels of IL-1 occurring in human seminal plasma. Reactive oxygen species-related sperm membrane peroxidation may be one mechanism by which cytokines can exert a detrimental effect on male fertility. This study suggests a new mechanism by which cell-mediated immunological male infertility may occur.Entities:
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Year: 1994 PMID： 8005288 DOI： 10.1016/s0015-0282(16)56838-1
Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329