Literature DB >> 8004760

Effect of mitomycin C, verapamil, and hyperthermia on human gastric adenocarcinoma.

I B Shchepotin1, R R Buras, R J Nauta, M Shabahang, S R Evans.   

Abstract

The purpose of this study was to assess the efficacy of verapamil (20 microM) and hyperthermia (42 degrees C) as modifiers of mitomycin C (MMC), used at different concentrations, in inhibiting the growth of human gastric adenocarcinoma (AGS) cells. Combined verapamil and hyperthermia treatment resulted in a significant decrease in cell count by 72.2% as compared with the control value. Verapamil drastically enhanced the growth-inhibitory activity of MMC at high concentration against AGS cells by 67.5% and had no effect at intermediate and low concentrations. Hyperthermia did not enhance the effect of MMC on AGS cells. The modalities analyzed in this study require further investigation and may have potential for in vivo studies on gastric cancer therapy in the near future.

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Year:  1994        PMID： 8004760     DOI： 10.1007/BF00685086

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  28 in total

1.  Sensitivity of human cells to mild hyperthermia.

Authors:  E P Armour; D McEachern; Z Wang; P M Corry; A Martinez
Journal:  Cancer Res       Date:  1993-06-15       Impact factor: 12.701

2.  Effects of amiloride on thermosensitivity of Chinese hamster cells under neutral and acidic pH.

Authors:  J Miyakoshi; W Oda; M Hirata; N Fukuhori; C Inagaki
Journal:  Cancer Res       Date:  1986-04       Impact factor: 12.701

3.  The response of human and rodent cells to hyperthermia.

Authors:  L Roizin-Towle; J P Pirro
Journal:  Int J Radiat Oncol Biol Phys       Date:  1991-04       Impact factor: 7.038

4.  Thermal biology and physiology in clinical hyperthermia: current status and future needs.

Authors:  G C Li
Journal:  Cancer Res       Date:  1984-10       Impact factor: 12.701

5.  Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients.

Authors:  R F Ozols; R E Cunnion; R W Klecker; T C Hamilton; Y Ostchega; J E Parrillo; R C Young
Journal:  J Clin Oncol       Date:  1987-04       Impact factor: 44.544

6.  Hyperthermia potentiates the cytotoxic activity of 1-hexylcarbamoyl-5-fluorouracil in sarcoma-180 cells and human malignant tumor cells.

Authors:  T Kusumoto; Y Maehara; Y Sakaguchi; S Kohnoe; K Sugimachi
Journal:  Anticancer Res       Date:  1991 Nov-Dec       Impact factor: 2.480

7.  Cytohistologic assessment of antitumor effects of intraperitoneal hyperthermic perfusion with mitomycin C for patients with gastric cancer with peritoneal metastasis.

Authors:  S Fujimoto; M Takahashi; K Kobayashi; K Nagano; M Kure; T Mutoh; H Ohkubo
Journal:  Cancer       Date:  1992-12-15       Impact factor: 6.860

8.  Potentiation of platinum analogue cytotoxicity by hyperthermia.

Authors:  M J Xu; D S Alberts
Journal:  Cancer Chemother Pharmacol       Date:  1988       Impact factor: 3.333

9.  Thermal sensitivity and resistance of insulin-receptor binding.

Authors:  S K Calderwood; G M Hahn
Journal:  Biochim Biophys Acta       Date:  1983-03-15

10.  Resistance of human glioma to adriamycin in vitro: the role of membrane transport and its circumvention with verapamil.

Authors:  S Merry; C A Fetherston; S B Kaye; R I Freshney; J A Plumb
Journal:  Br J Cancer       Date:  1986-01       Impact factor: 7.640
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