BACKGROUND: The frequency with which squamous cell carcinoma (SCC) of the skin metastasizes is a matter of dispute. Studies from private practices have reported much lower rates than hospital-based surveys, and one school of thought is that SCCs which arise in sun-damaged skin have a low risk of metastasis. METHODS: A prospective study of out-patients with histologically confirmed SCC was undertaken in southern Australia, a region with a very high incidence of skin cancer. RESULTS: Between November 1988 and November 1989, 481 patients were entered into the study and 420 followed for at least 3 years. An SCC was the initial diagnosis for 73 patients, 3 were immunosuppressed and 2 had an SCC of the lip, leaving 68 immunocompetent patients with SCC of the skin. Metastatic SCC developed in 2 patients (5.8% adjusted for losses) within 3 years. The SCCs were small and arose in sun-damaged skin. CONCLUSION: Patients with SCC of the skin need a careful follow-up because of the risk of metastasis.
BACKGROUND: The frequency with which squamous cell carcinoma (SCC) of the skin metastasizes is a matter of dispute. Studies from private practices have reported much lower rates than hospital-based surveys, and one school of thought is that SCCs which arise in sun-damaged skin have a low risk of metastasis. METHODS: A prospective study of out-patients with histologically confirmed SCC was undertaken in southern Australia, a region with a very high incidence of skin cancer. RESULTS: Between November 1988 and November 1989, 481 patients were entered into the study and 420 followed for at least 3 years. An SCC was the initial diagnosis for 73 patients, 3 were immunosuppressed and 2 had an SCC of the lip, leaving 68 immunocompetent patients with SCC of the skin. Metastatic SCC developed in 2 patients (5.8% adjusted for losses) within 3 years. The SCCs were small and arose in sun-damaged skin. CONCLUSION:Patients with SCC of the skin need a careful follow-up because of the risk of metastasis.
Authors: Sharifeh Farasat; Siegrid S Yu; Victor A Neel; Kishwer S Nehal; Thomas Lardaro; Martin C Mihm; David R Byrd; Charles M Balch; Joseph A Califano; Alice Y Chuang; William H Sharfman; Jatin P Shah; Paul Nghiem; Clark C Otley; Anthony P Tufaro; Timothy M Johnson; Arthur J Sober; Nanette J Liégeois Journal: J Am Acad Dermatol Date: 2011-01-20 Impact factor: 11.527
Authors: Michael Sand; Daniel Sand; Christina Thrandorf; Volker Paech; Peter Altmeyer; Falk G Bechara Journal: Head Face Med Date: 2010-06-04 Impact factor: 2.151
Authors: Matthew Fox; Marc Brown; Nicholas Golda; Dori Goldberg; Christopher Miller; Melissa Pugliano-Mauro; Chrysalyne Schmults; Thuzar Shin; Thomas Stasko; Yaohui G Xu; Kishwer Nehal Journal: J Am Acad Dermatol Date: 2018-09-15 Impact factor: 11.527
Authors: Jasbani H S Dayal; Clare L Cole; Celine Pourreyron; Stephen A Watt; Yok Zuan Lim; Julio C Salas-Alanis; Dedee F Murrell; John A McGrath; Bruno Stieger; Colin Jahoda; Irene M Leigh; Andrew P South Journal: J Cell Sci Date: 2013-12-19 Impact factor: 5.285
Authors: Fawaz M Makki; Adrian I Mendez; S Mark Taylor; Jonathan Trites; Martin Bullock; Gordon Flowerdew; Robert D Hart Journal: J Otolaryngol Head Neck Surg Date: 2013-02-05