Literature DB >> 8003668

6-Hydroxydopamine lesions reduce BDNF mRNA levels in adult rat brain substantia nigra.

J L Venero1, K D Beck, F Hefti.   

Abstract

Expression of brain-derived neurotrophic factor (BDNF) in the ventral mesencephalon has been assayed by mRNA in situ hybridization in adult rats with unilateral injections of 6-hydroxydopamine in the substantia nigra. On contralateral control sides, a specific hybridization signal was detected in the substantia nigra pars compacta (A9), ventral tegmental area (A10) and substantia nigra pars lateralis (A8). Cellular levels of BDNF mRNA were lower than those in BDNF expressing cortical and hippocampal neurons. The 6-hydroxydopamine injections completely abolished BDNF mRNA labeling in the pars compacta of the substantia nigra, whereas many labeled neurons remained in the ventral tegmental area and pars lateralis. The results strongly suggest that BDNF is expressed by nigral dopaminergic neurons.

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Year:  1994        PMID： 8003668     DOI： 10.1097/00001756-199401120-00014

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  6 in total

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Review 4.  Toxin-induced models of Parkinson's disease.

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5.  The transfection of BDNF to dopamine neurons potentiates the effect of dopamine D3 receptor agonist recovering the striatal innervation, dendritic spines and motor behavior in an aged rat model of Parkinson's disease.

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Journal:  PLoS One       Date:  2015-02-18       Impact factor: 3.240

6.  Alterations of BDNF and trkB mRNA expression in the 6-hydroxydopamine-induced model of preclinical stages of Parkinson's disease: an influence of chronic pramipexole in rats.

Authors:  Klemencja Berghauzen-Maciejewska; Jadwiga Wardas; Barbara Kosmowska; Urszula Głowacka; Katarzyna Kuter; Krystyna Ossowska
Journal:  PLoS One       Date:  2015-03-04       Impact factor: 3.240
  6 in total

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