OBJECTIVE: To study the long-term effects of supplementation with omega-3 fatty acids (omega 3) in patients with active rheumatoid arthritis. METHODS:Ninety patients were enrolled in a 12-month, double-blind, randomized study comparing daily supplementations with either 2.6 gm of omega 3, or 1.3 gm of omega 3 + 3 gm of olive oil, or 6 gm of olive oil. RESULTS: Significant improvement in the patient's global evaluation and in the physician's assessment of pain was observed only in those taking 2.6 gm/day of omega 3. The proportions of patients who improved and of those who were able to reduce their concomitant antirheumatic medications were significantly greater with 2.6 gm/day of omega 3. CONCLUSION: Daily supplementation with 2.6 gm of omega 3 results in significant clinical benefit and may reduce the need for concomitant antirheumatic medication.
RCT Entities:
OBJECTIVE: To study the long-term effects of supplementation with omega-3 fatty acids (omega 3) in patients with active rheumatoid arthritis. METHODS: Ninety patients were enrolled in a 12-month, double-blind, randomized study comparing daily supplementations with either 2.6 gm of omega 3, or 1.3 gm of omega 3 + 3 gm of olive oil, or 6 gm of olive oil. RESULTS: Significant improvement in the patient's global evaluation and in the physician's assessment of pain was observed only in those taking 2.6 gm/day of omega 3. The proportions of patients who improved and of those who were able to reduce their concomitant antirheumatic medications were significantly greater with 2.6 gm/day of omega 3. CONCLUSION: Daily supplementation with 2.6 gm of omega 3 results in significant clinical benefit and may reduce the need for concomitant antirheumatic medication.
Authors: Wooki Kim; Naim A Khan; David N McMurray; Ian A Prior; Naisyin Wang; Robert S Chapkin Journal: Prog Lipid Res Date: 2010-02-20 Impact factor: 16.195
Authors: Lisa D Yee; Joanne L Lester; Rachel M Cole; Julia R Richardson; Jason C Hsu; Yan Li; Amy Lehman; Martha A Belury; Steven K Clinton Journal: Am J Clin Nutr Date: 2010-03-24 Impact factor: 7.045
Authors: L Kesavalu; B Vasudevan; B Raghu; E Browning; D Dawson; J M Novak; M C Correll; M J Steffen; A Bhattacharya; G Fernandes; J L Ebersole Journal: J Dent Res Date: 2006-07 Impact factor: 6.116
Authors: L Hooper; R L Thompson; R A Harrison; C D Summerbell; H Moore; H V Worthington; P N Durrington; A R Ness; N E Capps; G Davey Smith; R A Riemersma; S B J Ebrahim Journal: Cochrane Database Syst Rev Date: 2004-10-18