Literature DB >> 8003011

The nitric oxide-scavenging properties of Ginkgo biloba extract EGb 761.

L Marcocci1, J J Maguire, M T Droy-Lefaix, L Packer.   

Abstract

Ginkgo biloba extract EGb 761 was found to be a scavenger of nitric oxide in in vitro acellular systems, under physiological conditions. EGb 761 competed with oxyhemoglobin for reaction with nitric oxide generated during the interaction of hydroxylamine with Complex I of catalase. An EGb 761 dose-dependent decrease in the amount of nitrite formed in the reaction of oxygen with nitric oxide produced from solution of 5 mM sodium nitroprusside was also observed. These data implicate it as a potential therapeutic agent in conditions of altered production of nitric oxide.

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Year:  1994        PMID： 8003011     DOI： 10.1006/bbrc.1994.1764

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  128 in total

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