Literature DB >> 8002988

Translation initiation from non-AUG codons in COS1 cells is mRNA species dependent.

K C Gupta1, E Ono, E V Ariztia, M Inaba.   

Abstract

Sendai virus P/C mRNA, human erythrocyte membrane protein 4.1 mRNA and PDGF-B chain mRNA were used to test whether translation initiation from non-AUG codons in COS1 cells was mRNA species dependent. Site-directed mutants of the authentic translation start sites of these mRNAs to alternate start codons showed that while P/C mRNA is capable of initiating translation from non-AUG start sites the other two mRNAs are not. Our study shows that translation initiation from non-AUG codons is mRNA species dependent and suggests that higher order structure of an mRNA determines the non-AUG translation start site.

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Year:  1994        PMID： 8002988     DOI： 10.1006/bbrc.1994.1739

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

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Authors:  Adly M M Abd-Alla; Henry M Kariithi; François Cousserans; Nicolas J Parker; İkbal Agah İnce; Erin D Scully; Sjef Boeren; Scott M Geib; Solomon Mekonnen; Just M Vlak; Andrew G Parker; Marc J B Vreysen; Max Bergoin
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6.  Characterization of the termination-reinitiation strategy employed in the expression of influenza B virus BM2 protein.

Authors:  Michael L Powell; Sawsan Napthine; Richard J Jackson; Ian Brierley; T David K Brown
Journal:  RNA       Date:  2008-09-29       Impact factor: 4.942
  6 in total

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