Literature DB >> 8002385

Structures of new 18-membered macrolides FD-891 and FD-892.

M Seki-Asano1, Y Tsuchida, K Hanada, K Mizoue.   

Abstract

Structures of FD-891 and FD-892 were determined by extensive NMR spectral analysis as shown in Fig. 1. They belong to such 18-membered macrolides as concanamycins and virustomycin.

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Year:  1994        PMID： 8002385     DOI： 10.7164/antibiotics.47.1234

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  4 in total

1.  Synthesis and structure-activity relationship study of FD-891: importance of the side chain and C8-C9 epoxide for cytotoxic activity against cancer cells.

Authors:  Tomohiro Itagaki; Ayano Kawamata; Miho Takeuchi; Keisuke Hamada; Yoshiharu Iwabuchi; Tadashi Eguchi; Fumitaka Kudo; Takeo Usui; Naoki Kanoh
Journal:  J Antibiot (Tokyo)       Date:  2016-01-27       Impact factor: 2.649

2.  FD-891, a structural analogue of concanamycin A that does not affect vacuolar acidification or perforin activity, yet potently prevents cytotoxic T lymphocyte-mediated cytotoxicity through the blockage of conjugate formation.

Authors:  T Kataoka; A Yamada; M Bando; T Honma; K Mizoue; K Nagai
Journal:  Immunology       Date:  2000-06       Impact factor: 7.397

3.  Enantioselective total synthesis of FD-891.

Authors:  Michael T Crimmins; Franck Caussanel
Journal:  J Am Chem Soc       Date:  2006-03-15       Impact factor: 15.419

Review 4.  Macrocyclic drugs and synthetic methodologies toward macrocycles.

Authors:  Xufen Yu; Dianqing Sun
Journal:  Molecules       Date:  2013-05-24       Impact factor: 4.411
  4 in total

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