Literature DB >> 8001769

Characterization of the aac(6')-Ik gene of Acinetobacter sp. 6.

E Rudant1, P Bourlioux, P Courvalin, T Lambert.   

Abstract

The aac(6')-Ik gene which confers resistance to aminoglycosides in Acinetobacter sp. 6 CIP A165 was characterized. The resistance gene was identified as a coding sequence of 438 bases pairs corresponding to a protein with a calculated mass of 16627 Da. Alignment of aac(6')-Ik with aac(6')-Ig from Acinetobacter haemolyticus indicated 83% identity. Like aac(6')-Ig of A. haemolyticus and aac(6')-Ij of Acinetobacter sp. 13, the aac(6')-Ik gene was apparently located in the chromosome and was species specific. The high degree of identity between aac(6')-Ig and -Ik, compared with genomic DNA relationships between the host species, indicated that these genes have diverged from a common ancestor in a parental Acinetobacter species.

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Year:  1994        PMID： 8001769     DOI： 10.1016/0378-1097(94)90331-x

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  11 in total

1.  Systematic analysis of a conserved region of the aminoglycoside 6'-N-acetyltransferase type Ib.

Authors:  A Shmara; N Weinsetel; K J Dery; R Chavideh; M E Tolmasky
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2.  Cloning and characterization of an aminoglycoside 6'-N-acetyltransferase gene from Citrobacter freundii which confers an altered resistance profile.

Authors:  H Y Wu; G H Miller; M G Blanco; R S Hare; K J Shaw
Journal:  Antimicrob Agents Chemother       Date:  1997-11       Impact factor: 5.191

3.  Characterization of the chromosomal aac(6')-Iz gene of Stenotrophomonas maltophilia.

Authors:  T Lambert; M C Ploy; F Denis; P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1999-10       Impact factor: 5.191

4.  Characterization of the chromosomal aminoglycoside 2'-N-acetyltransferase gene from Mycobacterium fortuitum.

Authors:  J A Aínsa; C Martin; B Gicquel; R Gomez-Lus
Journal:  Antimicrob Agents Chemother       Date:  1996-10       Impact factor: 5.191

Review 5.  Aminoglycoside modifying enzymes.

Authors:  Maria S Ramirez; Marcelo E Tolmasky
Journal:  Drug Resist Updat       Date:  2010-09-15       Impact factor: 18.500

6.  Integron carrying a novel metallo-beta-lactamase gene, blaIMP-16, and a fused form of aminoglycoside-resistant gene aac(6')-30/aac(6')-Ib': report from the SENTRY Antimicrobial Surveillance Program.

Authors:  Rodrigo E Mendes; Mark A Toleman; Julival Ribeiro; Helio S Sader; Ronald N Jones; Timothy R Walsh
Journal:  Antimicrob Agents Chemother       Date:  2004-12       Impact factor: 5.191

7.  Characterization of the 6'-N-aminoglycoside acetyltransferase gene aac(6')-Im [corrected] associated with a sulI-type integron.

Authors:  E Hannecart-Pokorni; F Depuydt; L de wit; E van Bossuyt; J Content; R Vanhoof
Journal:  Antimicrob Agents Chemother       Date:  1997-02       Impact factor: 5.191

8.  Loss of intrinsic aminoglycoside resistance in Acinetobacter haemolyticus as a result of three distinct types of alterations in the aac(6')-Ig gene, including insertion of IS17.

Authors:  E Rudant; P Courvalin; T Lambert
Journal:  Antimicrob Agents Chemother       Date:  1997-12       Impact factor: 5.191

Review 9.  Versatility of aminoglycosides and prospects for their future.

Authors:  Sergei B Vakulenko; Shahriar Mobashery
Journal:  Clin Microbiol Rev       Date:  2003-07       Impact factor: 26.132

10.  Spread of novel aminoglycoside resistance gene aac(6')-Iad among Acinetobacter clinical isolates in Japan.

Authors:  Yohei Doi; Jun-Ichi Wachino; Kunikazu Yamane; Naohiro Shibata; Tetsuya Yagi; Keigo Shibayama; Haru Kato; Yoshichika Arakawa
Journal:  Antimicrob Agents Chemother       Date:  2004-06       Impact factor: 5.191
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