Literature DB >> 8001686

The widely used anesthetic agent propofol can replace alpha-tocopherol as an antioxidant.

L Aarts1, R van der Hee, I Dekker, J de Jong, H Langemeijer, A Bast.   

Abstract

The cell membrane is protected against lipid peroxidation through endogenous antioxidants such as the lipid soluble alpha-tocopherol. The anesthetic agent propofol (2,6-diisopropylphenol) has a chemical structure which is similar to alpha-tocopherol, since it also contains a phenolic OH-group. The transient protection of GSH against lipid peroxidation in control liver microsomes is not observed in microsomes deficient in alpha-tocopherol. Introducing propofol (2 and 5 microM) restored the protective effect of GSH. Similar to the control microsomes the GSH-protective effect did not occur in previously heated microsomes. These results suggest that propofol acts similarly to alpha-tocopherol as a chain breaking antioxidant in liver microsomal membranes.

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Year:  1995        PMID： 8001686     DOI： 10.1016/0014-5793(94)01337-z

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  21 in total

Review 1.  Anesthetics, immune cells, and immune responses.

Authors:  Shin Kurosawa; Masato Kato
Journal:  J Anesth       Date:  2008-08-07       Impact factor: 2.078

2.  Propofol Suppresses LPS-Induced Inflammation in Amnion Cells via Inhibition of NF-κB Activation.

Authors:  Ji-Young Yoon; Do-Wan Kim; Ji-Hye Ahn; Eun-Ji Choi; Yeon Ha Kim; Moonjung Jeun; Eun-Jung Kim
Journal:  Tissue Eng Regen Med       Date:  2019-05-29       Impact factor: 4.169

3.  Propofol prevents endothelial dysfunction induced by glucose overload.

Authors:  Yuji Karashima; Masahiro Oike; Shosuke Takahashi; Yushi Ito
Journal:  Br J Pharmacol       Date:  2002-11       Impact factor: 8.739

4.  Propofol attenuates oxidant-induced acute lung injury in an isolated perfused rabbit-lung model.

Authors:  Masato Yumoto; Osamu Nishida; Fujio Nakamura; Hirotada Katsuya
Journal:  J Anesth       Date:  2005       Impact factor: 2.078

5.  Lipid peroxidation and the use of emulsified propofol in laparoscopic surgery.

Authors:  A D Manataki; A D Tselepis; G K Glantzounis; H M Arnaoutoglou; E C Tsimoyiannis; N E Stavropoulos
Journal:  Surg Endosc       Date:  2001-06-12       Impact factor: 4.584

Review 6.  Propofol. An update of its use in anaesthesia and conscious sedation.

Authors:  H M Bryson; B R Fulton; D Faulds
Journal:  Drugs       Date:  1995-09       Impact factor: 9.546

7.  Cardioprotective effects of anesthetic preconditioning in rats with ischemia-reperfusion injury: propofol versus isoflurane.

Authors:  Xing Tao; Ling-qiao Lu; Qing Xu; Shu-ren Li; Mao-tsun Lin
Journal:  J Zhejiang Univ Sci B       Date:  2009-10       Impact factor: 3.066

Review 8.  Propofol. An overview of its pharmacology and a review of its clinical efficacy in intensive care sedation.

Authors:  B Fulton; E M Sorkin
Journal:  Drugs       Date:  1995-10       Impact factor: 9.546

9.  Propofol protects against hydrogen peroxide-induced oxidative stress and cell dysfunction in human umbilical vein endothelial cells.

Authors:  Jiawei Chen; Yuechao Gu; Zhiming Shao; Jianmin Luo; Zhiming Tan
Journal:  Mol Cell Biochem       Date:  2009-12-29       Impact factor: 3.396

10.  Effects of propofol, a sedative-hypnotic drug, on the lipid profile, antioxidant indices, and cardiovascular marker enzymes in wistar rats.

Authors:  Oluwatosin A Adaramoye; Olugbenga Akinwonmi; Olubukola Akanni
Journal:  ISRN Pharmacol       Date:  2013-06-06
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