Literature DB >> 7998845

Replication of human cytomegalovirus in a rhabdomyosarcoma cell line depends on the state of differentiation of the cells.

J Cinatl1, J Cinatl1, K Radsak, H Rabenau, B Weber, M Novak, R Benda, B Kornhuber, H W Doerr.   

Abstract

The replication of human cytomegalovirus (HCMV) was investigated in a new human rhabdomyosarcoma cell line (KFR) with morphological and biochemical characteristics of fetal striated muscle precursors (rhabdomyoblasts). KFR cells exhibited the unique property for spontaneous morphological transformation from a poorly-differentiated state into well-differentiated (myotube-like) rhabdomyoblasts. The poorly-differentiated rhabdomyoblasts promoted both complete viral gene expression and the production of infectious virus. In contrast, in well-differentiated rhabdomyoblasts HCMV infection was abortive. The results showed that replication of HCMV in this human rhabdomyosarcoma cell line depended on the state of cellular differentiation.

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Year:  1994        PMID： 7998845     DOI： 10.1007/BF01379143

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  30 in total

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4.  12-O-tetradecanoylphorbol-13-acetate-induced differentiation of a human rhabdomyosarcoma cell line.

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5.  Immunohistochemical detection of an immediate early antigen of human cytomegalovirus in normal tissues.

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  8 in total

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Review 3.  Oncomodulation by human cytomegalovirus: novel clinical findings open new roads.

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4.  Human cytomegalovirus infection of tumor cells downregulates NCAM (CD56): a novel mechanism for virus-induced tumor invasiveness.

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5.  Cytomegalovirus infection leads to pleomorphic rhabdomyosarcomas in Trp53+/- mice.

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6.  Enzastaurin inhibits ABCB1-mediated drug efflux independently of effects on protein kinase C signalling and the cellular p53 status.

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7.  Selection of a highly invasive neuroblastoma cell population through long-term human cytomegalovirus infection.

Authors:  M Michaelis; S Barth; R Breitling; J Bruch; D Steinberger; F Rothweiler; K Hackmann; E Schröck; H W Doerr; D K Griffin; J Cinatl; J Cinatl
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8.  Latent infection of human cytomegalovirus is associated with the development of gastric cancer.

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  8 in total

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