Stereotactic biopsy for intrinsic lesions of the medulla through the long-axis of the brainstem: technical considerations.

The authors report the technique and results for stereotactic biopsy of intrinsic lesions of the medulla oblongata through the long-axis of the brainstem. Multi-planar stereotactic magnetic resonance imaging and/or reformatted computed tomography imaging is used for coordinate determination and trajectory selection and facilitates a completely intra-axial pathway through critical neural tissue. Two patients with small, solitary, enhancing lesions of the medulla had stereotactic sampling via this approach performed under local anesthesia. There was no morbidity and in both the patients a histologic diagnosis of lymphoma was obtained. We believe that with high-resolution, multi-planar stereotactic imaging, small lesions in the medulla can safely be biopsied, avoiding the need for either posterior fossa craniectomy and open biopsy, or for empiric management.