| Literature DB >> 7998395 |
R K Usmanov, M S Balaian, O V Dvoĭnikova, D B Alymbaeva, N A Zamiatina, Iu A Kazachkov, V I Belov.
Abstract
Lambs were experimentally infected with a pool of 10% hepatitis E (HE) patient fecal suspension containing HE virus (HEV) isolates Osh-225 and Osh-228 which caused an infection closely resembling experimental HE in primates. Clinical manifestations consisted of acute biochemical and histological hepatitis, virus shedding in feces, the presence of virus-like particles in the peripharyngeal lymph nodes and the contents of small intestine, of HEV RNA in the parenchymal organs of lambs. Susceptibility of lambs to HEV derived from the infected piglets and the possibility of passaging the piglets' HEV in lambs was demonstrated. This passaging led to shortening of the incubation period.Entities:
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Year: 1994 PMID： 7998395
Source DB: PubMed Journal: Vopr Virusol ISSN： 0507-4088