Literature DB >> 7997462

Antinociceptive mechanism of the aconitine alkaloids mesaconitine and benzoylmesaconine.

Y Suzuki1, T Oyama, A Ishige, T Isono, A Asami, Y Ikeda, M Noguchi, Y Omiya.   

Abstract

We explored the possible role of the specific regions in the brain stem on the antinociceptive actions of mesaconitine (MA) and benzoylmesaconine (BM) by the microinjection of MA and BM into nucleus reticularis paragigantocellularis (NRPG), nucleus raphe magnus (NRM), and periaqueductal gray (PAG). MA microinjected into NRPG, NRM, or PAG elicited a dose-dependent antinociceptive action, whereas BM injected into NRM or PAG elicited a dose-dependent antinociceptive action but not in NRPG. The NRM appeared to be the most sensitive region among the three tested locations.

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Year:  1994        PMID： 7997462     DOI： 10.1055/s-2006-959516

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  12 in total

1.  Determination of aconitine in body fluids by LC-MS-MS.

Authors:  J Beike; L Frommherz; M Wood; B Brinkmann; H Köhler
Journal:  Int J Legal Med       Date:  2004-10       Impact factor: 2.686

2.  Frequency-dependent inhibition of neuronal activity by lappaconitine in normal and epileptic hippocampal slices.

Authors:  A Ameri; P Metzmeier; T Peters
Journal:  Br J Pharmacol       Date:  1996-06       Impact factor: 8.739

3.  Antioxidant and Nephroprotective Activities of Aconitum heterophyllum Root in Glycerol Induced Acute Renal Failure in Rats.

Authors:  Venu Gopala Rao Konda; Madhavi Eerike; Lakshmipathy Prabhu Raghuraman; Maignana Kumar Rajamanickam
Journal:  J Clin Diagn Res       Date:  2016-03-01

4.  Aconitine inhibits epileptiform activity in rat hippocampal slices.

Authors:  A Ameri; J Gleitz; T Peters
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-06       Impact factor: 3.000

5.  14-Benzoyl-mesaconine hydro-chloride methanol monosolvate.

Authors:  Yan Mu; Lin Li; Hai-Liu Wei; Tong-Chun Kuang; Song-Qing Hu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-03-26

6.  Identification of key transporters mediating uptake of aconitum alkaloids into the liver and kidneys and the potential mechanism of detoxification by active ingredients of liquorice.

Authors:  Yufei He; Ze Wang; Weidang Wu; Ying Xie; Zihong Wei; Xiulin Yi; Yong Zeng; Yazhuo Li; Changxiao Liu
Journal:  RSC Adv       Date:  2019-05-23       Impact factor: 4.036

7.  A comparative study on the traditional Indian Shodhana and Chinese processing methods for aconite roots by characterization and determination of the major components.

Authors:  Yogini Jaiswal; Zhitao Liang; Peng Yong; Hubiao Chen; Zhongzhen Zhao
Journal:  Chem Cent J       Date:  2013-10-25       Impact factor: 4.215

8.  An optimized high-performance liquid chromatography (HPLC) method for benzoylmesaconine determination in Radix Aconiti Lateralis Preparata (Fuzi, aconite roots) and its products.

Authors:  Ying Xie; Hua Zhou; Yuen Fan Wong; Zhongqiu Liu; Hongxi Xu; Zhihong Jiang; Liang Liu
Journal:  Chin Med       Date:  2008-05-30       Impact factor: 5.455

9.  Monoester-Diterpene Aconitum Alkaloid Metabolism in Human Liver Microsomes: Predominant Role of CYP3A4 and CYP3A5.

Authors:  Ling Ye; Xiao-Shan Yang; Lin-Lin Lu; Wei-Ying Chen; Shan Zeng; Tong-Meng Yan; Ling-Na Dong; Xiao-Juan Peng; Jian Shi; Zhong-Qiu Liu
Journal:  Evid Based Complement Alternat Med       Date:  2013-06-23       Impact factor: 2.629

10.  Systems Pharmacology and Verification of ShenFuHuang Formula in Zebrafish Model Reveal Multi-Scale Treatment Strategy for Septic Syndrome in COVID-19.

Authors:  Tengwen Liu; Yuhong Guo; Jingxia Zhao; Shasha He; Yunjing Bai; Ning Wang; Yan Lin; Qingquan Liu; Xiaolong Xu
Journal:  Front Pharmacol       Date:  2020-09-15       Impact factor: 5.810
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