Literature DB >> 7997262

Crystal structure of the tyrosine kinase domain of the human insulin receptor.

S R Hubbard1, L Wei, L Ellis, W A Hendrickson.   

Abstract

The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 A resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is bound in the active site.

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Year:  1994        PMID： 7997262     DOI： 10.1038/372746a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  237 in total

1.  Three dimensional atomic model and experimental validation for the ATP-Regulated Module (ARM) of the atrial natriuretic factor receptor guanylate cyclase.

Authors:  T Duda; P Yadav; A Jankowska; V Venkataraman; R K Sharma
Journal:  Mol Cell Biochem       Date:  2001-01       Impact factor: 3.396

2.  Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family.

Authors:  R M Katso; R B Russell; T S Ganesan
Journal:  Mol Cell Biol       Date:  1999-09       Impact factor: 4.272

3.  Regulation of neuregulin-mediated acetylcholine receptor synthesis by protein tyrosine phosphatase SHP2.

Authors:  M Tanowitz; J Si; D H Yu; G S Feng; L Mei
Journal:  J Neurosci       Date:  1999-11-01       Impact factor: 6.167

4.  Three dimensional atomic model and experimental validation for the ATP-Regulated Module (ARM) of the atrial natriuretic factor receptor guanylate cyclase.

Authors:  T Duda; P Yadav; A Jankowska; V Venkataraman; R K Sharma
Journal:  Mol Cell Biochem       Date:  2000-11       Impact factor: 3.396

5.  A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling.

Authors:  T C Yeh; E Dondi; G Uze; S Pellegrini
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-01       Impact factor: 11.205

6.  Identification of four candidate cGMP targets in Dictyostelium.

Authors:  Jonathan M Goldberg; Leonard Bosgraaf; Peter J M Van Haastert; Janet L Smith
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-14       Impact factor: 11.205

7.  Constructing and validating initial Cα models from subnanometer resolution density maps with pathwalking.

Authors:  Mariah R Baker; Ian Rees; Steven J Ludtke; Wah Chiu; Matthew L Baker
Journal:  Structure       Date:  2012-03-07       Impact factor: 5.006

8.  Cation-pi interactions studied in a model coiled-coil peptide.

Authors:  Morris M Slutsky; E Neil G Marsh
Journal:  Protein Sci       Date:  2004-07-06       Impact factor: 6.725

9.  Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells.

Authors:  Zheng-Long Yuan; Ying-Jie Guan; Lijuan Wang; Wenyi Wei; Agnes B Kane; Y Eugene Chin
Journal:  Mol Cell Biol       Date:  2004-11       Impact factor: 4.272

10.  Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis.

Authors:  B J Longley; D D Metcalfe; M Tharp; X Wang; L Tyrrell; S Z Lu; D Heitjan; Y Ma
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-16       Impact factor: 11.205
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