Literature DB >> 7995654

The potential of mild testicular heating as a safe, effective and reversible contraceptive method for men.

R Mieusset1, L Bujan.   

Abstract

A preliminary assessment of the contraceptive efficacy of a daily mild increase (1-2 degrees C) in testicular temperature during waking hours is reported in nine couples using two techniques of non-surgical fixation of the testes close to the inguinal canal. With technique 1, immobilization was achieved by passing the penis and the empty scrotum through a hole made in close-fitting underwear; there was one pregnancy, from a man who stopped the heating after 7 weeks, for 42 cycles of exposure in three couples. With technique 2, immobilization was achieved by adding a ring of soft material surrounding the hole in the underwear; there was no pregnancy for 117 cycles of exposure in six couples. Reversibility and safety were assessed. These preliminary results suggest that a daily mild increase in testicular temperature could be a potential contraceptive method for men.

Entities:  

Keywords:  Biology; Contraception; Contraception Research; Developed Countries; Europe; Examinations And Diagnoses; Family Planning; France; Genitalia; Genitalia, Male; Longitudinal Studies; Male Contraception; Mediterranean Countries; Physical Examinations And Diagnoses; Physiology; Research Report; Studies; Testis; Urogenital System; Western Europe

Mesh:

Year:  1994        PMID: 7995654     DOI: 10.1111/j.1365-2605.1994.tb01241.x

Source DB:  PubMed          Journal:  Int J Androl        ISSN: 0105-6263


  18 in total

Review 1.  How vulnerable is the developing testis to the external environment?

Authors:  P I Hughes
Journal:  Arch Dis Child       Date:  2000-10       Impact factor: 3.791

2.  Scrotal temperature is increased in disposable plastic lined nappies.

Authors:  C J Partsch; M Aukamp; W G Sippell
Journal:  Arch Dis Child       Date:  2000-10       Impact factor: 3.791

3.  Androgen suppression-induced stimulation of spermatogonial differentiation in juvenile spermatogonial depletion mice acts by elevating the testicular temperature.

Authors:  Gunapala Shetty; Karen L Porter; Wei Zhou; Shan H Shao; Connie C Y Weng; Marvin L Meistrich
Journal:  Endocrinology       Date:  2011-07-05       Impact factor: 4.736

Review 4.  Ignorance but not bliss: too little is known about the determinants of semen quality.

Authors:  W C L Ford
Journal:  Asian J Androl       Date:  2013-01-14       Impact factor: 3.285

5.  Increasing testicular temperature by exposure to elevated ambient temperatures restores spermatogenesis in adult Utp14b (jsd) mutant (jsd) mice.

Authors:  P B Comish; L Y Liang; Y Yamauchi; C C Weng; G Shetty; K A Naff; M A Ward; M L Meistrich
Journal:  Andrology       Date:  2014-10-09       Impact factor: 3.842

Review 6.  Environmental/lifestyle effects on spermatogenesis.

Authors:  Richard M Sharpe
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2010-05-27       Impact factor: 6.237

7.  A single, mild, transient scrotal heat stress causes hypoxia and oxidative stress in mouse testes, which induces germ cell death.

Authors:  Catriona Paul; Serena Teng; Philippa T K Saunders
Journal:  Biol Reprod       Date:  2009-01-14       Impact factor: 4.285

8.  Choice of underwear and male fecundity in a preconception cohort of couples.

Authors:  K J Sapra; M L Eisenberg; S Kim; Z Chen; G M Buck Louis
Journal:  Andrology       Date:  2016-03-03       Impact factor: 3.842

9.  Autophagy and apoptosis act as partners to induce germ cell death after heat stress in mice.

Authors:  Mianqiu Zhang; Min Jiang; Ye Bi; Hui Zhu; Zuomin Zhou; Jiahao Sha
Journal:  PLoS One       Date:  2012-07-25       Impact factor: 3.240

10.  Male contraception.

Authors:  Vivek Mathew; Ganapathi Bantwal
Journal:  Indian J Endocrinol Metab       Date:  2012-11
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