Literature DB >> 7994557

Human carcinoma cell lines produce biologically active leukemia inhibitory factor (LIF).

H Kamohara1, K Sakamoto, T Ishiko, S Mita, Y Masuda, T Abe, M Ogawa.   

Abstract

We investigated the production of leukemia inhibitory factor (LIF) by human carcinoma cell lines. LIF mRNA was detected by Northern blot analysis in all 24 carcinoma cell lines of the lung, breast, stomach, colon, liver, gallbladder, pancreas and melanocytes. Seventeen of them (70.8%) secreted LIF in the culture supernatant (range: 40.4-3990.3 pg/ml, mean +/- SEM: 611.8 +/- 262.9 pg/ml). Biologic activity of LIF was confirmed in the culture supernatant of carcinoma cell lines by the MTT assay using M1 cells. The present results showed that human carcinoma cell lines are constitutively producing biologically active LIF. The possible biological significance of LIF produced by cancer cells is discussed.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7994557

Source DB:  PubMed          Journal:  Res Commun Mol Pathol Pharmacol        ISSN： 1078-0297


  6 in total

1.  Expression and function of leukaemia inhibitory factor and its receptor in normal and regenerating rat pancreas.

Authors:  S De Breuck; L Baeyens; L Bouwens
Journal:  Diabetologia       Date:  2005-12-21       Impact factor: 10.122

2.  Expression of leukemia inhibitory factor in human pituitary adenomas: a morphologic and immunocytochemical study.

Authors:  G Kontogeorgos; H Patralexis; A Tran; K Kovacs; S Melmed
Journal:  Pituitary       Date:  2000-05       Impact factor: 4.107

3.  Gprc5a deletion enhances the transformed phenotype in normal and malignant lung epithelial cells by eliciting persistent Stat3 signaling induced by autocrine leukemia inhibitory factor.

Authors:  Yulong Chen; Jiong Deng; Junya Fujimoto; Humam Kadara; Taoyan Men; Dafna Lotan; Reuben Lotan
Journal:  Cancer Res       Date:  2010-10-19       Impact factor: 12.701

4.  An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy.

Authors:  Sean A Hunter; Brianna J McIntosh; Yu Shi; R Andres Parra Sperberg; Chie Funatogawa; Louai Labanieh; Erin Soon; Hannah C Wastyk; Nishant Mehta; Catherine Carter; Tony Hunter; Jennifer R Cochran
Journal:  Commun Biol       Date:  2021-04-12

Review 5.  IL-6: The Link Between Inflammation, Immunity and Breast Cancer.

Authors:  Juan Chen; Yanghui Wei; Weiqin Yang; Qingnan Huang; Yong Chen; Kai Zeng; Jiawei Chen
Journal:  Front Oncol       Date:  2022-07-18       Impact factor: 5.738

6.  Differential mechanisms of constitutive Akt/PKB activation and its influence on gene expression in pancreatic cancer cells.

Authors:  Joe Matsumoto; Masako Kaneda; Mitsuhiro Tada; Jun-ichi Hamada; Shunichi Okushiba; Satoshi Kondo; Hiroyuki Katoh; Tetsuya Moriuchi
Journal:  Jpn J Cancer Res       Date:  2002-12
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.