Literature DB >> 7994402

PEG-hemoglobin: an efficient oxygen-delivery system in the rat exchange transfusion and hypovolemic shock models.

K Nho1, R Linberg, M Johnson, C Gilbert, R Shorr.   

Abstract

Polyethylene glycol-hemoglobin (PEG-Hb is a purified bovine hemoglobin molecule modified by polyethylene glycol. Oxygen delivery to the tissue, in rat exchange transfusion and hypovolemic shock models, was studied to determine whether the oxygen-carrying capacity of PEG-Hb is as efficient as red blood cells.

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Year:  1994        PMID： 7994402     DOI： 10.3109/10731199409117913

Source DB:  PubMed          Journal:  Artif Cells Blood Substit Immobil Biotechnol        ISSN： 1073-1199


  2 in total

1.  Conjugation of multiple copies of polyethylene glycol to hemoglobin facilitated through thiolation: influence on hemoglobin structure and function.

Authors:  Belur N Manjula; Amy G Tsai; Marcos Intaglietta; Ching-Hsuan Tsai; Chien Ho; Paul K Smith; Krishnaveni Perumalsamy; Nirmala Devi Kanika; Joel M Friedman; Seetharama A Acharya
Journal:  Protein J       Date:  2005-04       Impact factor: 2.371

2.  Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute.

Authors:  Chris E Cooper; Gary G A Silkstone; Michelle Simons; Badri Rajagopal; Natalie Syrett; Thoufieq Shaik; Svetlana Gretton; Elizabeth Welbourn; Leif Bülow; Nélida Leiva Eriksson; Luca Ronda; Andrea Mozzarelli; Andras Eke; Domokos Mathe; Brandon J Reeder
Journal:  Free Radic Biol Med       Date:  2018-12-27       Impact factor: 7.376
  2 in total

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