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Literature DB >> 7993959

Serotonin and alcohol intake, abuse, and dependence: clinical evidence.

Abstract

A large body of literature has emerged concerning the role of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) in the regulation of alcohol intake and the development of alcoholism. Despite the wealth of information, the functional significance of this neurotransmitter remains to be fully elucidated. This paper, part one of a two-part review, summarizes the available clinical research along two lines: the effects of alcohol on serotonergic functioning and the effects of pharmacological manipulation of serotonergic functioning on alcohol intake in normal (nonalcohol dependent) and alcohol-dependent individuals. It is concluded that considerable evidence exists to support the notion that some alcoholic individuals may have lowered central serotonin neurotransmission.

Entities: Chemical Disease

Mesh：

Substances：
Serotonin

Year: 1994 PMID： 7993959 DOI： 10.1016/0006-3223(94)90630-0

Source DB: PubMed Journal: Biol Psychiatry ISSN： 0006-3223 Impact factor: 13.382

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Cited

64 in total

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2. Structural and functional modifications in glutamateric synapses following prolonged ethanol exposure.

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Journal: Alcohol Clin Exp Res Date: 2006-02 Impact factor: 3.455

3. Can serotonin transporter genotype predict serotonergic function, chronicity, and severity of drinking?

Authors: Bankole A Johnson; Martin A Javors; John D Roache; Chamindi Seneviratne; Susan E Bergeson; Nassima Ait-Daoud; Michael A Dawes; Jennie Z Ma
Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2007-08-19 Impact factor: 5.067

4. Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphé differentially affect serotonin release in the nucleus accumbens.

Authors: Jodi L Lukkes; Gina L Forster; Kenneth J Renner; Cliff H Summers
Journal: Eur J Pharmacol Date: 2007-10-02 Impact factor: 4.432

5. Personality profile in type I alcoholism: long duration of alcohol intake and low serotonergic activity are predictive factors of anxiety proneness.

Authors: K Berglund; C Fahlke; U Berggren; M Eriksson; J Balldin
Journal: J Neural Transm (Vienna) Date: 2006-02-06 Impact factor: 3.575

Serotonin and alcohol intake, abuse, and dependence: clinical evidence.

Review 1. What are the costs of marital conflict and dissolution to children's physical health?

2. Structural and functional modifications in glutamateric synapses following prolonged ethanol exposure.

3. Can serotonin transporter genotype predict serotonergic function, chronicity, and severity of drinking?

4. Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphé differentially affect serotonin release in the nucleus accumbens.

5. Personality profile in type I alcoholism: long duration of alcohol intake and low serotonergic activity are predictive factors of anxiety proneness.

6. Can serotonin transporter genotype predict craving in alcoholism?

Review 7. A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity.

Review 8. Relapse Prevention in Alcoholism : Recent Advances and Future Possibilities.

Review 9. In vitro and in vivo models of acute alcohol exposure.

10. Prediction of serotonergic treatment efficacy using age of onset and Type A/B typologies of alcoholism.