Literature DB >> 7993078

Inhibition of the growth of influenza viruses in vitro by 4-guanidino-2,4-dideoxy-N-acetylneuraminic acid.

G P Thomas1, M Forsyth, C R Penn, J W McCauley.   

Abstract

The sialidase inhibitor 4-guanidino-2,4-dideoxy-2,3-dehydro-N- acetylneuraminic acid was tested for growth inhibitory effects against a panel of avian influenza A viruses encompassing all nine neuraminidase subtypes. Growth in tissue culture of viruses from each subtype was inhibited by this compound at concentrations within a range previously found effective against human N1 and N2 viruses. This compound may prove a selective agent for the treatment (and prevention) of influenza virus infections.

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Year:  1994        PMID： 7993078     DOI： 10.1016/0166-3542(94)90081-7

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  13 in total

Review 1.  Zanamivir.

Authors:  S L Waghorn; K L Goa
Journal:  Drugs       Date:  1998-05       Impact factor: 9.546

2.  Generation and characterization of a mutant of influenza A virus selected with the neuraminidase inhibitor BCX-140.

Authors:  S Bantia; A A Ghate; S L Ananth; Y S Babu; G M Air; G M Walsh
Journal:  Antimicrob Agents Chemother       Date:  1998-04       Impact factor: 5.191

3.  Safety and efficacy of intravenous zanamivir in preventing experimental human influenza A virus infection.

Authors:  D P Calfee; A W Peng; L M Cass; M Lobo; F G Hayden
Journal:  Antimicrob Agents Chemother       Date:  1999-07       Impact factor: 5.191

4.  Characterization of mutants of influenza A virus selected with the neuraminidase inhibitor 4-guanidino-Neu5Ac2en.

Authors:  L V Gubareva; R Bethell; G J Hart; K G Murti; C R Penn; R G Webster
Journal:  J Virol       Date:  1996-03       Impact factor: 5.103

Review 5.  Zanamivir: an update of its use in influenza.

Authors:  Susan M Cheer; Antona J Wagstaff
Journal:  Drugs       Date:  2002       Impact factor: 9.546

6.  Efficacy of zanamivir against avian influenza A viruses that possess genes encoding H5N1 internal proteins and are pathogenic in mammals.

Authors:  I A Leneva; O Goloubeva; R J Fenton; M Tisdale; R G Webster
Journal:  Antimicrob Agents Chemother       Date:  2001-04       Impact factor: 5.191

Review 7.  Zanamivir: a review of its use in influenza.

Authors:  C J Dunn; K L Goa
Journal:  Drugs       Date:  1999-10       Impact factor: 9.546

8.  Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection.

Authors:  D B Mendel; C Y Tai; P A Escarpe; W Li; R W Sidwell; J H Huffman; C Sweet; K J Jakeman; J Merson; S A Lacy; W Lew; M A Williams; L Zhang; M S Chen; N Bischofberger; C U Kim
Journal:  Antimicrob Agents Chemother       Date:  1998-03       Impact factor: 5.191

9.  Characterization of human influenza virus variants selected in vitro in the presence of the neuraminidase inhibitor GS 4071.

Authors:  C Y Tai; P A Escarpe; R W Sidwell; M A Williams; W Lew; H Wu; C U Kim; D B Mendel
Journal:  Antimicrob Agents Chemother       Date:  1998-12       Impact factor: 5.191

Review 10.  New approaches to influenza chemotherapy. Neuraminidase inhibitors.

Authors:  D P Calfee; F G Hayden
Journal:  Drugs       Date:  1998-10       Impact factor: 9.546
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