Literature DB >> 7993077

Use of a flavivirus RNA-dependent RNA polymerase assay to investigate the antiviral activity of selected compounds.

A Bartholomeusz1, E Tomlinson, P J Wright, C Birch, S Locarnini, H Weigold, S Marcuccio, G Holan.   

Abstract

We have developed an assay using flavivirus RNA-dependent RNA polymerase to test the inhibitory activity of potential antiviral agents. The effects of antiviral agents on RNA synthesis were examined in this assay using extracts of Vero cells infected with dengue virus type 2 or Kunjin virus. Several different classes of known polymerase inhibitors were tested. The synthesis of double-stranded replicative form RNA was inhibited in a dose-dependent fashion in the presence of the polyoxometalate HPA-23 [(NH4)18(NaW21Sb9O86)17].14 H2O and several structurally related compounds.

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Year:  1994        PMID： 7993077     DOI： 10.1016/0166-3542(94)90080-9

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  3 in total

Review 1.  Perspectives for the treatment of infections with Flaviviridae.

Authors:  P Leyssen; E De Clercq; J Neyts
Journal:  Clin Microbiol Rev       Date:  2000-01       Impact factor: 26.132

2.  Synergistic anti-influenza virus A (H1N1) activities of PM-523 (polyoxometalate) and ribavirin in vitro and in vivo.

Authors:  S Shigeta; S Mori; J Watanabe; S Soeda; K Takahashi; T Yamase
Journal:  Antimicrob Agents Chemother       Date:  1997-07       Impact factor: 5.191

Review 3.  Structure and functionality in flavivirus NS-proteins: perspectives for drug design.

Authors:  Michela Bollati; Karin Alvarez; René Assenberg; Cécile Baronti; Bruno Canard; Shelley Cook; Bruno Coutard; Etienne Decroly; Xavier de Lamballerie; Ernest A Gould; Gilda Grard; Jonathan M Grimes; Rolf Hilgenfeld; Anna M Jansson; Hélène Malet; Erika J Mancini; Eloise Mastrangelo; Andrea Mattevi; Mario Milani; Grégory Moureau; Johan Neyts; Raymond J Owens; Jingshan Ren; Barbara Selisko; Silvia Speroni; Holger Steuber; David I Stuart; Torsten Unge; Martino Bolognesi
Journal:  Antiviral Res       Date:  2009-11-27       Impact factor: 5.970
  3 in total

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