Literature DB >> 7992817

Anti-nociceptive effects of aconiti tuber and its alkaloids.

T Oyama1, T Isono, Y Suzuki, Y Hayakawa.   

Abstract

The anti-nociceptive effect of processed aconiti tuber (TJ-3021), one of the traditional oriental herbal medicines (Kampo), was investigated by utilizing various methods including repeated cold stress and adjuvant articular inflammation in rats and mice. Analgesic potency was compared with that of mesaconitine, a potent component of aconitine alkaloids, and other analgesic agents. It was found that mesaconitine was more potent than morphine, and a processed aconiti tuber [(TJ-3021), Tsumura-shuchi-bushi-matsu] showed some analgesic effect, although it was weaker than those of dichlofenac, aminopyrine and indomethacine.

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Year:  1994        PMID： 7992817     DOI： 10.1142/S0192415X94000218

Source DB:  PubMed          Journal:  Am J Chin Med        ISSN： 0192-415X            Impact factor:   4.667


  6 in total

1.  Aconitine facilitates spontaneous transmitter release at rat ventromedial hypothalamic neurons.

Authors:  Hisashi Yamanaka; Atsushi Doi; Hitoshi Ishibashi; Norio Akaike
Journal:  Br J Pharmacol       Date:  2002-02       Impact factor: 8.739

2.  Ignavine: a novel allosteric modulator of the μ opioid receptor.

Authors:  Katsuya Ohbuchi; Chika Miyagi; Yasuyuki Suzuki; Yasuharu Mizuhara; Keita Mizuno; Yuji Omiya; Masahiro Yamamoto; Eiji Warabi; Yuka Sudo; Akinobu Yokoyama; Kanako Miyano; Takatsugu Hirokawa; Yasuhito Uezono
Journal:  Sci Rep       Date:  2016-08-17       Impact factor: 4.379

3.  Diverse TRPV1 responses to cannabinoids.

Authors:  J Starkus; C Jansen; L M N Shimoda; A J Stokes; A L Small-Howard; H Turner
Journal:  Channels (Austin)       Date:  2019-12       Impact factor: 2.581

Review 4.  Neuropharmacological Effects of Mesaconitine: Evidence from Molecular and Cellular Basis of Neural Circuit.

Authors:  Zhihui Sun; Limin Yang; Lihong Zhao; Ranji Cui; Wei Yang
Journal:  Neural Plast       Date:  2020-08-21       Impact factor: 3.599

5.  Mother root of Aconitum carmichaelii Debeaux exerts antinociceptive effect in Complet Freund's Adjuvant-induced mice: roles of dynorpin/kappa-opioid system and transient receptor potential vanilloid type-1 ion channel.

Authors:  Chao Wang; Danni Sun; Chunfang Liu; Chunyan Zhu; Xianghong Jing; Shuping Chen; Cuiling Liu; Kai Zhi; Tengfei Xu; Hui Wang; Junling Liu; Ying Xu; Zhiqiang Liu; Na Lin
Journal:  J Transl Med       Date:  2015-08-30       Impact factor: 5.531

6.  Significance of Kampo, traditional Japanese medicine, in supportive care of cancer patients.

Authors:  Jun-Ichi Yamakawa; Yoshiharu Motoo; Junji Moriya; Masao Ogawa; Hiroaki Uenishi; Sumiyo Akazawa; Toshiyuki Sasagawa; Matomo Nishio; Junji Kobayashi
Journal:  Evid Based Complement Alternat Med       Date:  2013-06-19       Impact factor: 2.629
  6 in total

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