Literature DB >> 7990737

Parkinson's disease: a chronic, low-grade antioxidant deficiency?

C R Burkhardt1, H K Weber.   

Abstract

The cause of Parkinson's disease (PD) is aggressively being pursued. Several hypotheses have been advanced, yet none of these completely explains the large body of evidence research has already uncovered. A new hypothesis, that PD is caused by a chronic antioxidant deficiency state, is outlined in this article. Oxidative stress, mitochondrial abnormalities, epidemiology, genetics, toxins, history of PD and diet are discussed.

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Year:  1994        PMID： 7990737     DOI： 10.1016/0306-9877(94)90060-4

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN： 0306-9877            Impact factor:   1.538


  10 in total

Review 1.  Targeting urate to reduce oxidative stress in Parkinson disease.

Authors:  Grace F Crotty; Alberto Ascherio; Michael A Schwarzschild
Journal:  Exp Neurol       Date:  2017-06-13       Impact factor: 5.330

2.  Plasma thiamine deficiency associated with Alzheimer's disease but not Parkinson's disease.

Authors:  M Gold; R A Hauser; M F Chen
Journal:  Metab Brain Dis       Date:  1998-03       Impact factor: 3.584

3.  Serum urate and probability of dopaminergic deficit in early "Parkinson's disease".

Authors:  Michael A Schwarzschild; Kenneth Marek; Shirley Eberly; David Oakes; Ira Shoulson; Danna Jennings; John Seibyl; Alberto Ascherio
Journal:  Mov Disord       Date:  2011-04-29       Impact factor: 10.338

4.  Intake of antioxidant vitamins and risk of Parkinson's disease.

Authors:  Katherine C Hughes; Xiang Gao; Iris Y Kim; Eric B Rimm; Molin Wang; Marc G Weisskopf; Michael A Schwarzschild; Alberto Ascherio
Journal:  Mov Disord       Date:  2016-10-27       Impact factor: 10.338

Review 5.  Urate: a novel biomarker of Parkinson's disease risk, diagnosis and prognosis.

Authors:  Sara Cipriani; Xiqun Chen; Michael A Schwarzschild
Journal:  Biomark Med       Date:  2010-10       Impact factor: 2.851

6.  Urate as a predictor of the rate of clinical decline in Parkinson disease.

Authors:  Alberto Ascherio; Peter A LeWitt; Kui Xu; Shirley Eberly; Arthur Watts; Wayne R Matson; Connie Marras; Karl Kieburtz; Alice Rudolph; Mikhail B Bogdanov; Steven R Schwid; Marsha Tennis; Caroline M Tanner; M Flint Beal; Anthony E Lang; David Oakes; Stanley Fahn; Ira Shoulson; Michael A Schwarzschild
Journal:  Arch Neurol       Date:  2009-12

7.  Critical Role of Oxidatively Damaged DNA in Selective Noradrenergic Vulnerability.

Authors:  Yanqiang Zhan; Muhammad U Raza; Lian Yuan; Meng-Yang Zhu
Journal:  Neuroscience       Date:  2019-11-05       Impact factor: 3.708

8.  ABCG2 variant has opposing effects on onset ages of Parkinson's disease and gout.

Authors:  Hirotaka Matsuo; Hiroyuki Tomiyama; Wataru Satake; Toshinori Chiba; Hiroyuki Onoue; Yusuke Kawamura; Akiyoshi Nakayama; Seiko Shimizu; Masayuki Sakiyama; Manabu Funayama; Kenya Nishioka; Toru Shimizu; Kenichi Kaida; Keiko Kamakura; Tatsushi Toda; Nobutaka Hattori; Nariyoshi Shinomiya
Journal:  Ann Clin Transl Neurol       Date:  2015-01-19       Impact factor: 4.511

9.  Treadmill exercise alleviates nigrostriatal dopaminergic loss of neurons and fibers in rotenone-induced Parkinson rats.

Authors:  Mal-Soon Shin; Tae-Woon Kim; Jae-Min Lee; Eun-Sang Ji; Baek-Vin Lim
Journal:  J Exerc Rehabil       Date:  2017-02-28

Review 10.  Epidemiology of Parkinson's disease.

Authors:  C M Tanner; S M Goldman
Journal:  Neurol Clin       Date:  1996-05       Impact factor: 3.806
  10 in total

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