Literature DB >> 7990147

Crystallization and preliminary X-ray studies of the diphtheria Tox repressor from Corynebacterium diphtheriae.

N Schiering1, X Tao, J R Murphy, G A Petsko, D Ringe.   

Abstract

Crystals of the diphtheria tox repressor (DtxR) from Corynebacterium diphtheriae suitable for structure determination have been obtained. DtxR activated with transition metal ions represses the expression of the structural gene for the diphtheria toxin, tox, which is encoded on the genome of a family of closely related corynebacteriophages. The space group of the obtained crystals is trigonal P3(1)21 or its enantiomorph P3(2)21 with a = b = 64.2 A, c = 220.5 A, alpha = beta = 90 degrees, gamma = 120 degrees. Two monomers comprise the asymmetric unit. The crystals diffract to a resolution of better than 3 A.

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Year:  1994        PMID： 7990147     DOI： 10.1006/jmbi.1994.1760

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  5 in total

1.  Identification and characterization of three new promoter/operators from Corynebacterium diphtheriae that are regulated by the diphtheria toxin repressor (DtxR) and iron.

Authors:  J H Lee; T Wang; K Ault; J Liu; M P Schmitt; R K Holmes
Journal:  Infect Immun       Date:  1997-10       Impact factor: 3.441

2.  Transition metal ion activation of DNA binding by the diphtheria tox repressor requires the formation of stable homodimers.

Authors:  X Tao; H Y Zeng; J R Murphy
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-18       Impact factor: 11.205

3.  Structures of the apo- and the metal ion-activated forms of the diphtheria tox repressor from Corynebacterium diphtheriae.

Authors:  N Schiering; X Tao; H Zeng; J R Murphy; G A Petsko; D Ringe
Journal:  Proc Natl Acad Sci U S A       Date:  1995-10-10       Impact factor: 11.205

4.  SirR, a novel iron-dependent repressor in Staphylococcus epidermidis.

Authors:  P J Hill; A Cockayne; P Landers; J A Morrissey; C M Sims; P Williams
Journal:  Infect Immun       Date:  1998-09       Impact factor: 3.441

Review 5.  Corynebacterium diphtheriae: Diphtheria Toxin, the tox Operon, and Its Regulation by Fe2+ Activation of apo-DtxR.

Authors:  Sadiya Parveen; William R Bishai; John R Murphy
Journal:  Microbiol Spectr       Date:  2019-07
  5 in total

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