Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The human RAD51/RecA homologue gene is not a candidate gene for Bloom's syndrome.

Literature DB >> 7989048

The human RAD51/RecA homologue gene is not a candidate gene for Bloom's syndrome.

D Hellgren¹, S Sahlén, S Ljungqvist, K Kenne.

Abstract

The human gene HSRAD51/RecA homologue has been investigated as a possible candidate gene involved in Bloom's syndrome. No mutations were found in the cDNA isolated from three different Bloom's syndrome cell lines, thus excluding the possibility that HSRAD51 is directly involved in the syndrome. Other possible candidates are discussed.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1994 PMID： 7989048 DOI： 10.1007/BF00206968

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

Keyword Cloud
References

21 in total

1. An abnormal profile of DNA replication intermediates in Bloom's syndrome.

Authors: U Lönn; S Lönn; U Nylen; G Winblad; J German
Journal: Cancer Res Date: 1990-06-01 Impact factor: 12.701

2. Assignment of the gene encoding DNA ligase I to human chromosome 19q13.2-13.3.

Authors: D E Barnes; K Kodama; K Tynan; B J Trask; M Christensen; P J De Jong; N K Spurr; T Lindahl; H W Mohrenweiser
Journal: Genomics Date: 1992-01 Impact factor: 5.736

3. Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents.

Authors: D E Barnes; A E Tomkinson; A R Lehmann; A D Webster; T Lindahl
Journal: Cell Date: 1992-05-01 Impact factor: 41.582

The human RAD51/RecA homologue gene is not a candidate gene for Bloom's syndrome.

1. An abnormal profile of DNA replication intermediates in Bloom's syndrome.

2. Assignment of the gene encoding DNA ligase I to human chromosome 19q13.2-13.3.

3. Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents.

4. Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein.

5. DNA ligase I deficiency in Bloom's syndrome.

6. Altered DNA ligase I activity in Bloom's syndrome cells.

7. Evidence for increased in vivo mutation and somatic recombination in Bloom's syndrome.

8. Elevated spontaneous mutation rate in Bloom syndrome fibroblasts.

9. Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA.

10. Similarity of the yeast RAD51 filament to the bacterial RecA filament.