Literature DB >> 7988682

Expression of cytochrome P-450 3A in HT29-MTX cells and Caco-2 clone TC7.

V Carrière1, T Lesuffleur, A Barbat, M Rousset, E Dussaulx, P Costet, I de Waziers, P Beaune, A Zweibaum.   

Abstract

HT-29 sublines and Caco-2 clones were analyzed for the expression of cytochrome P-450 3A. The enzyme was found to be expressed in differentiated HT-29 cells selected by resistance to methotrexate and in one of seven Caco-2 clones, TC7. Its expression parallels the differentiation process, with highest levels being observed at late confluency. P-450 3A mRNA and protein patterns, as well as subcellular distribution, are intermediate between those observed in human adult intestine and fetal liver.

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Year:  1994        PMID： 7988682     DOI： 10.1016/0014-5793(94)01199-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

1.  Comparison of CYP3A activities in a subclone of Caco-2 cells (TC7) and human intestine.

Authors:  S D Raeissi; Z Guo; G L Dobson; P Artursson; I J Hidalgo
Journal:  Pharm Res       Date:  1997-08       Impact factor: 4.200

2.  Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4.

Authors:  C L Crespi; B W Penman; M Hu
Journal:  Pharm Res       Date:  1996-11       Impact factor: 4.200

3.  Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers.

Authors:  S D Raeissi; I J Hidalgo; J Segura-Aguilar; P Artursson
Journal:  Pharm Res       Date:  1999-05       Impact factor: 4.200

Review 4.  The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications.

Authors:  V Meunier; M Bourrié; Y Berger; G Fabre
Journal:  Cell Biol Toxicol       Date:  1995-08       Impact factor: 6.691

5.  Transport and metabolic characterization of Caco-2 cells expressing CYP3A4 and CYP3A4 plus oxidoreductase.

Authors:  M Hu; Y Li; C M Davitt; S M Huang; K Thummel; B W Penman; C L Crespi
Journal:  Pharm Res       Date:  1999-09       Impact factor: 4.200

6.  Primary porcine enterocyte and hepatocyte cultures to study drug oxidation reactions.

Authors:  A Bader; T Hansen; G Kirchner; C Allmeling; A Haverich; J T Borlak
Journal:  Br J Pharmacol       Date:  2000-01       Impact factor: 8.739

7.  Transepithelial transport of HIV-1 by M cells is receptor-mediated.

Authors:  Grigorios Fotopoulos; Alexandre Harari; Pierre Michetti; Didier Trono; Giuseppe Pantaleo; Jean-Pierre Kraehenbuhl
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-01       Impact factor: 11.205

8.  Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction.

Authors:  G Bertilsson; J Heidrich; K Svensson; M Asman; L Jendeberg; M Sydow-Bäckman; R Ohlsson; H Postlind; P Blomquist; A Berkenstam
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-13       Impact factor: 11.205

9.  Use of In Vitro and Predictive In Silico Models to Study the Inhibition of Cytochrome P4503A by Stilbenes.

Authors:  Loai Basheer; Keren Schultz; Merav Fichman; Zohar Kerem
Journal:  PLoS One       Date:  2015-10-20       Impact factor: 3.240

10.  Isolation and characterization of human primary enterocytes from small intestine using a novel method.

Authors:  Priti Chougule; Gustaf Herlenius; Nidia Maritza Hernandez; Pradeep B Patil; Bo Xu; Suchitra Sumitran-Holgersson
Journal:  Scand J Gastroenterol       Date:  2012-09-04       Impact factor: 2.423
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