Literature DB >> 7988648

Effect of valepotriates on the behavior of rats in the elevated plus-maze during diazepam withdrawal.

R Andreatini1, J R Leite.   

Abstract

The effect of a mixture of valepotriates on the elevated plus-maze performance of diazepam withdrawn rats was evaluated. The rats were chronically (28 days) treated with diazepam (doses increased up to 5.0 mg/kg) and then treated with control solution for 3 days to induce a withdrawal syndrome. Chronically vehicle-treated rats were used as control. The abstinent animals treated with vehicle showed a significant decrease in the percentage of time spent in the open arms when compared with the control animals. Diazepam and valerian 12.0 mg/kg reversed this anxiogenic effect. Valerian 6.0 mg/kg did not show any difference in relation to the others group.

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Year:  1994        PMID： 7988648     DOI： 10.1016/0014-2999(94)90342-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Herbal Medicine: Is it an Alternative or an Unknown? A Brief Review of Popular Herbals Used by Patients in a Pain and Symptom Management Practice Setting.

Authors: 
Journal:  Curr Rev Pain       Date:  1999

Review 2.  Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence.

Authors:  Jerome Sarris; Erica McIntyre; David A Camfield
Journal:  CNS Drugs       Date:  2013-04       Impact factor: 5.749

3.  Effects of Valeriana officinalis extracts on [3H]flunitrazepam binding, synaptosomal [3H]GABA uptake, and hippocampal [3H]GABA release.

Authors:  J G Ortiz; J Nieves-Natal; P Chavez
Journal:  Neurochem Res       Date:  1999-11       Impact factor: 3.996

4.  Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with [H]Glutamate Binding to Rat Synaptic Membranes.

Authors:  Lisa M Del Valle-Mojica; Yoshira M Ayala-Marín; Carmen M Ortiz-Sanchez; Bianca A Torres-Hernández; Safa Abdalla-Mukhaimer; José G Ortiz
Journal:  Evid Based Complement Alternat Med       Date:  2011-04-26       Impact factor: 2.629

5.  Diene Valepotriates from Valeriana glechomifolia Prevent Lipopolysaccharide-Induced Sickness and Depressive-Like Behavior in Mice.

Authors:  Liz G Müller; Milene Borsoi; Eveline D Stolz; Vivian Herzfeldt; Alice F Viana; Ana Paula Ravazzolo; Stela Maris K Rates
Journal:  Evid Based Complement Alternat Med       Date:  2015-06-11       Impact factor: 2.629

6.  Inhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis.

Authors:  Tong Sun; Yujia Xu; Zhuan Xu; Biyin Cao; Zubin Zhang; Qi Wang; Yan Kong; Xinliang Mao
Journal:  Cell Commun Signal       Date:  2021-02-24       Impact factor: 5.712
  6 in total

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