Literature DB >> 7987812

Trisomy 11 and other nonrandom trisomies in congenital fibrosarcoma.

R Bernstein1, P M Zeltzer, F Lin, P M Carpenter.   

Abstract

Chromosome studies in a 7-week-old female infant with an intraabdominal malignant fibrosarcoma showed a hyperdiploid karyotype of 50,XX, +der(6)del(6)(p23)add(6)(q11), +8, +10, +11,add(12)(p13). Trisomy 11 appears to be a nonrandom primary cytogenetic abnormality in the congenital or infantile form of this mesenchymal tumor and is also a nonrandom gain in congenital mesoblastic nephroma. A possible developmental link between these two mesenchymal tumors, mediated by a gene or genes on chromosome 11 is postulated.

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Year:  1994        PMID： 7987812     DOI： 10.1016/0165-4608(94)90051-5

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  2 in total

1.  Cellular mesoblastic nephroma (infantile renal fibrosarcoma): institutional review of the clinical, diagnostic imaging, and pathologic features of a distinctive neoplasm of infancy.

Authors:  Petek Bayindir; Robert Paul Guillerman; M John Hicks; M Murali Chintagumpala
Journal:  Pediatr Radiol       Date:  2009-07-21

2.  Congenital mesoblastic nephroma t(12;15) is associated with ETV6-NTRK3 gene fusion: cytogenetic and molecular relationship to congenital (infantile) fibrosarcoma.

Authors:  B P Rubin; C J Chen; T W Morgan; S Xiao; H E Grier; H P Kozakewich; A R Perez-Atayde; J A Fletcher
Journal:  Am J Pathol       Date:  1998-11       Impact factor: 4.307
  2 in total

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