| Literature DB >> 7987701 |
R M Bluthé1, V Walter, P Parnet, S Layé, J Lestage, D Verrier, S Poole, B E Stenning, K W Kelley, R Dantzer.
Abstract
To assess the possibility that lipopolysaccharide (LPS) induces sickness behaviour by activating primary afferent nerves, the effects of LPS (1.25 mg kg-1, intraperitoneally) were compared in vagotomized and sham-operated rats. Subdiaphragmatic vagotomy blocked the LPS-induced depression of social investigation but had no effect on LPS-induced increases in levels of IL-1 beta in plasma and peritoneal macrophages and on LPS-induced changes in dehydrogenase activity of peritoneal macrophages.Entities:
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Year: 1994 PMID： 7987701
Source DB: PubMed Journal: C R Acad Sci III ISSN： 0764-4469