Literature DB >> 7987321

Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene.

M Peyrard1, I Fransson, Y G Xie, F Y Han, M H Ruttledge, S Swahn, J E Collins, I Dunham, V P Collins, J P Dumanski.   

Abstract

A 140 kb homozygous deletion from 22q12 in one meningioma directed us towards the cloning and characterization of a new member of the human beta-adaptin gene family (named BAM22). Adaptins are essential for the formation of clathrin coated vesicles in the course of intracellular transport of receptor-ligand complexes. The BAM22 gene is totally inactivated in the tumor with homozygous deletion. Northern blot analysis of 70 sporadic meningiomas showed specific loss of expression in 8 tumors, suggesting inactivation of BAM22. Based on this, we propose BAM22 as a second chromosome 22 locus important in meningioma development, after the neurofibromatosis type 2 gene.

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Year:  1994        PMID： 7987321     DOI： 10.1093/hmg/3.8.1393

Source DB:  PubMed          Journal:  Hum Mol Genet        ISSN： 0964-6906            Impact factor:   6.150


  17 in total

1.  Characterization of the mouse beta-prime adaptin gene; cDNA sequence, genomic structure, and chromosomal localization.

Authors:  C Guilbaud; M Peyrard; I Fransson; S W Clifton; B A Roe; N P Carter; J P Dumanski
Journal:  Mamm Genome       Date:  1997-09       Impact factor: 2.957

2.  Screening for mutations in the neurofibromatosis type 2 (NF2) gene in sporadic meningiomas.

Authors:  L R De Vitis; A Tedde; F Vitelli; F Ammannati; P Mennonna; U Bigozzi; E Montali; L Papi
Journal:  Hum Genet       Date:  1996-05       Impact factor: 4.132

3.  The human LARGE gene from 22q12.3-q13.1 is a new, distinct member of the glycosyltransferase gene family.

Authors:  M Peyrard; E Seroussi; A C Sandberg-Nordqvist; Y G Xie; F Y Han; I Fransson; J Collins; I Dunham; M Kost-Alimova; S Imreh; J P Dumanski
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-19       Impact factor: 11.205

4.  The mouse homolog of the bovine leukemia virus receptor is closely related to the delta subunit of adaptor-related protein complex AP-3, not associated with the cell surface.

Authors:  T Suzuki; H Ikeda
Journal:  J Virol       Date:  1998-01       Impact factor: 5.103

5.  Adaptins: the final recount.

Authors:  M Boehm; J S Bonifacino
Journal:  Mol Biol Cell       Date:  2001-10       Impact factor: 4.138

6.  Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: toward a genetic model of meningioma progression.

Authors:  R G Weber; J Boström; M Wolter; M Baudis; V P Collins; G Reifenberger; P Lichter
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-23       Impact factor: 11.205

Review 7.  Molecular pathogenesis of meningiomas.

Authors:  Arie Perry; David H Gutmann; Guido Reifenberger
Journal:  J Neurooncol       Date:  2004-11       Impact factor: 4.130

Review 8.  Pathological classification and molecular genetics of meningiomas.

Authors:  Christian Mawrin; Arie Perry
Journal:  J Neurooncol       Date:  2010-09-01       Impact factor: 4.130

9.  Age associated increase in the prevalence of chromosome 22q loss of heterozygosity in histological subsets of benign meningioma.

Authors:  M E Baser; T Y Poussaint
Journal:  J Med Genet       Date:  2005-06-24       Impact factor: 6.318

10.  Molecular heterogeneity of meningioma with INI1 mutation.

Authors:  P Rieske; M Zakrzewska; S Piaskowski; D Jaskólski; B Sikorska; W Papierz; K Zakrzewski; P P Liberski
Journal:  Mol Pathol       Date:  2003-10
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