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Literature DB >> 7986662

The antioxidant enzymes activity in the conditions of systemic hypersilicemia.

J Najda¹, M Goss, J Gmínski, L Weglarz, K Siemianowicz, Z Olszowy.

Abstract

The effect of an excessive inorganic silicon oral intake on the activity of basic antioxidant enzymes was studied in rats. Activities of superoxide dismutase, catalase, and glutathione peroxidase were measured in liver and kidney tissues of animals receiving per os sodium metasilicate nonahydrate (Na2SiO3.9H2O) (Sigma, [St. Louis, MO]) dissolved in their drinking water. A decrease of the activity of all the studied enzymes was found in the samples derived from the experimental group. The results obtained indicate the free oxygen radicals participation in the potential pathologic events in the conditions of systemic hypersilicemia.

Entities: Chemical Disease Gene Species

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Year: 1994 PMID： 7986662 DOI： 10.1007/BF02990489

Source DB: PubMed Journal: Biol Trace Elem Res ISSN： 0163-4984 Impact factor: 3.738

21 in total

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Authors: J W Dobbie; M J Smith
Journal: Scott Med J Date: 1982-01 Impact factor: 0.729

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Authors: D E Paglia; W N Valentine
Journal: J Lab Clin Med Date: 1967-07

3. Distribution of(31)Silicon-Labeled silicic acid in the rat.

Authors: G M Berlyne; R Shainkin-Kestenbaum; R Yagil; Z Alfassi; A Kushelevsky; Z Etzion
Journal: Biol Trace Elem Res Date: 1986-08 Impact factor: 3.738

4. Effect of aluminium on superoxide dismutase.

Authors: R Shainkin-Kestenbaum; A J Adler; G M Berlyne; C Caruso
Journal: Clin Sci (Lond) Date: 1989-11 Impact factor: 6.124

5. Inhibition of superoxide dismutase activity by silicon.

Authors: R Shainkin-Kestenbaum; A J Adler; G M Berlyne
Journal: J Trace Elem Electrolytes Health Dis Date: 1990-06

6. Experimental silicosis. II. Long-term effects of intratracheally instilled quartz on collagen metabolism and morphologic characteristics of rat lungs.

Authors: K M Reiser; W M Haschek; T W Hesterberg; J A Last
Journal: Am J Pathol Date: 1983-01 Impact factor: 4.307

The antioxidant enzymes activity in the conditions of systemic hypersilicemia.

1. The silicon content of body fluids.

2. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.

3. Distribution of(31)Silicon-Labeled silicic acid in the rat.

4. Effect of aluminium on superoxide dismutase.

5. Inhibition of superoxide dismutase activity by silicon.

6. Experimental silicosis. II. Long-term effects of intratracheally instilled quartz on collagen metabolism and morphologic characteristics of rat lungs.

7. Silicon metabolism. I. Some aspects of renal silicon handling in normal man.

8. The antiatheromatous action of silicon.

9. Study of fatty acids in atheroma induced in rabbits by an atherogenic diet with or without silicon i.v. treatment.

10. Increased incidence of malignancy in chronic renal failure.

1. Immunotoxicity evaluation of novel bioactive composites in male mice as promising orthopaedic implants.