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Literature DB >> 7986499

Antigen non-specific immunological tests in progressive sensorineural hearing loss.

M Savastano¹, C Raffael, G De Franchis, C Andreoli.

Abstract

The purpose of the present study was to determine the validity of antigen non-specific immunological tests in order to develop a risk-clinical profile of patients with immune-mediated inner ear pathology. The study was carried out on 38 patients with progressive sensorineural hearing loss and a control group of 26 subjects. Serological testing was used to determine cell activation complexes. In patients with hearing loss, T-lymphocyte subpopulations were found to have an increase in cytotoxic T-cells when compared to T-helper, but only for interleukin-2 receptor expression. This difference was significant between patients and the control group. Present findings suggest that T-lymphocyte "early" marker is of particular interest for developing a risk-clinical profile of patients with sensorineural progressive hearing loss of immune origin.

Entities: Disease Species

Mesh：

Substances：

Year: 1994 PMID： 7986499 DOI： 10.1007/BF00181884

Source DB: PubMed Journal: Eur Arch Otorhinolaryngol ISSN： 0937-4477 Impact factor: 2.503

12 in total

1. Activation of human thymocytes via the 50KD T11 sheep erythrocyte binding protein induces the expression of interleukin 2 receptors on both T3+ and T3- populations.

Authors: D A Fox; R E Hussey; K A Fitzgerald; A Bensussan; J F Daley; S F Schlossman; E L Reinherz
Journal: J Immunol Date: 1985-01 Impact factor: 5.422

2. Clinical diagnosis of immune inner-ear disease.

Authors: G B Hughes; B P Barna; S E Kinney; L H Calabrese; N J Nalepa
Journal: Laryngoscope Date: 1988-03 Impact factor: 3.325

3. Circulating immune complexes in steroid-responsive sensorineural hearing loss and the long-term observation.

Authors: J Kanzaki; T O-Uchi
Journal: Acta Otolaryngol Suppl Date: 1983

4. A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells.

Authors: T Uchiyama; S Broder; T A Waldmann
Journal: J Immunol Date: 1981-04 Impact factor: 5.422

5. A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. II. Expression of Tac antigen on activated cytotoxic killer T cells, suppressor cells, and on one of two types of helper T cells.

Authors: T Uchiyama; D L Nelson; T A Fleisher; T A Waldmann
Journal: J Immunol Date: 1981-04 Impact factor: 5.422

Antigen non-specific immunological tests in progressive sensorineural hearing loss.

1. Activation of human thymocytes via the 50KD T11 sheep erythrocyte binding protein induces the expression of interleukin 2 receptors on both T3+ and T3- populations.

2. Clinical diagnosis of immune inner-ear disease.

3. Circulating immune complexes in steroid-responsive sensorineural hearing loss and the long-term observation.

4. A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells.

5. A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. II. Expression of Tac antigen on activated cytotoxic killer T cells, suppressor cells, and on one of two types of helper T cells.

6. Practical versus theoretical management of autoimmune inner ear disease.

7. Autoimmune sensorineural hearing loss.

8. Autoimmunity and inner ear disorders: an immune-complex mediated sensorineural hearing loss.

9. Steroid-responsive bilateral sensorineural hearing loss and immune complexes.

10. Expression of Tac antigen on activated normal human B cells.

1. Non-specific immunological determinations in Meniere's disease: any role in clinical practice?